Rajnikant Sharma
Overview
Explore the profile of Rajnikant Sharma including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
235
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0
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Recent Articles
1.
Rojas L, Nielsen T, Pantapalangkoor P, Taracila M, Introvigne M, Sharma R, et al.
Antimicrob Agents Chemother
. 2025 Jan;
69(3):e0096424.
PMID: 39873501
Foremost in the design of new β-lactamase inhibitors (BLIs) are the boronic acid transition state inhibitors (BATSIs). Two highly potent BATSIs being developed are S02030 and MB076 strategically designed to...
2.
Rao G, Valle Q, Mahadevan R, Sharma R, Barr J, Van Tyne D
Clin Pharmacol Ther
. 2024 Sep;
117(1):94-105.
PMID: 39313763
Effectively treating multidrug-resistant bacterial infections remains challenging due to the limited drug development pipeline and a scarcity of novel agents effective against these highly resistant pathogens. Bacteriophages (phages) are a...
3.
Garcia E, Diep J, Sharma R, Rao G
Int J Antimicrob Agents
. 2024 Jan;
63(4):107100.
PMID: 38280574
Over the last decade, there has been a growing appreciation for the use of in vitro and in vivo infection models to generate robust and informative nonclinical PK/PD data to...
4.
Hussein M, Sun Z, Hawkey J, Allobawi R, Judd L, Carbone V, et al.
mSystems
. 2023 Dec;
9(1):e0097223.
PMID: 38078757
Nitrofurantoin is a commonly used chemotherapeutic agent in the treatment of uncomplicated urinary tract infections caused by the problematic multidrug resistant Gram-negative pathogen . The present study aims to elucidate...
5.
Mezcord V, Escalante J, Nishimura B, Traglia G, Sharma R, Valle Q, et al.
Int J Mol Sci
. 2023 Jul;
24(14).
PMID: 37511511
Infections caused by Carbapenem-resistant (CRAB) isolates, such as hospital-acquired pneumonia (HAP), bacteremia, and skin and soft tissue infections, among others, are particularly challenging to treat. Cefiderocol, a chlorocatechol-substituted siderophore antibiotic,...
6.
Hanafin P, Abdul Rahim N, Sharma R, Cess C, Finley S, Bergen P, et al.
CPT Pharmacometrics Syst Pharmacol
. 2023 Jan;
12(3):387-400.
PMID: 36661181
Carbapenemase-resistant Klebsiella pneumoniae (KP) resistant to multiple antibiotic classes necessitates optimized combination therapy. Our objective is to build a workflow leveraging omics and bacterial count data to identify antibiotic mechanisms...
7.
Lu J, Zhu Y, Parkington H, Hussein M, Zhao J, Bergen P, et al.
Mol Neurobiol
. 2022 Nov;
60(3):1317-1330.
PMID: 36443617
Intraventricular or intrathecal administration of polymyxins are increasingly used to treat multidrug-resistant (MDR) Gram-negative bacteria caused infections in the central nervous system (CNS). However, our limited knowledge of the mechanisms...
8.
Hussein M, Oberrauch S, Allobawi R, Cornthwaite-Duncan L, Lu J, Sharma R, et al.
Comput Struct Biotechnol J
. 2022 Nov;
20:6067-6077.
PMID: 36420146
There is a dearth of studies focused on understanding pharmacokinetics, pharmacodynamics and toxicodynamics of polymyxins following direct administration to the central nervous system (CNS). In this study, for the first...
9.
Luterbach C, Qiu H, Hanafin P, Sharma R, Piscitelli J, Lin F, et al.
Antimicrob Agents Chemother
. 2022 Sep;
66(10):e0059122.
PMID: 36125299
Antimicrobial resistance is a global threat. As "proof-of-concept," we employed a system-based approach to identify patient, bacterial, and drug variables contributing to mortality in patients with carbapenem-resistant Klebsiella pneumoniae (CR)...
10.
Sharma R, Yeshwante S, Valle Q, Hussein M, Thombare V, McCann S, et al.
J Vis Exp
. 2022 Sep;
(186).
PMID: 36094269
Burn induction methodologies are inconsistently described in rat models. A uniform burn wound model, which represents the clinical scenario, is necessary to perform reproducible burn research. The present protocol describes...