Rajith S Manan
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Explore the profile of Rajith S Manan including associated specialties, affiliations and a list of published articles.
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11
Citations
161
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Recent Articles
1.
Harvey L, Alotaibi M, Tai Y, Tang Y, Kim H, Kelly N, et al.
Science
. 2025 Jan;
387(6732):eadn7277.
PMID: 39847635
Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator...
2.
Jeang W, Wong B, Zhao Y, Manan R, Jiang A, Bose S, et al.
Adv Mater
. 2024 Dec;
37(7):e2414743.
PMID: 39722171
Immune reactions to medical implants often lead to encapsulation by fibrotic tissue and impaired device function. This process is thought to initiate by protein adsorption, which enables immune cells to...
3.
Witten J, Raji I, Manan R, Beyer E, Bartlett S, Tang Y, et al.
Nat Biotechnol
. 2024 Dec;
PMID: 39658727
Ionizable lipids are a key component of lipid nanoparticles, the leading nonviral messenger RNA delivery technology. Here, to advance the identification of ionizable lipids beyond current methods, which rely on...
4.
Jiang A, Lathwal S, Meng S, Witten J, Beyer E, McMullen P, et al.
J Am Chem Soc
. 2024 Nov;
146(47):32567-32574.
PMID: 39535145
Lipid nanoparticles (LNPs) have great potential to enable inhaled delivery of mRNA to treat pulmonary diseases. However, this potential has been limited by the challenge of nebulizing the LNPs. Nebulization...
5.
Jiang A, Witten J, Raji I, Eweje F, MacIsaac C, Meng S, et al.
Nat Nanotechnol
. 2023 Nov;
19(3):364-375.
PMID: 37985700
Inhaled delivery of mRNA has the potential to treat a wide variety of diseases. However, nebulized mRNA lipid nanoparticles (LNPs) face several unique challenges including stability during nebulization and penetration...
6.
Rhym L, Manan R, Koller A, Stephanie G, Anderson D
Nat Biomed Eng
. 2023 May;
7(7):901-910.
PMID: 37127709
Developing safe and effective nanoparticles for the delivery of messenger RNA (mRNA) is slow and expensive, partly due to the lack of predictive power of in vitro screening methods and...
7.
Gupta A, Andresen J, Manan R, Langer R
Adv Drug Deliv Rev
. 2021 Sep;
178:113834.
PMID: 34492233
Recent medical advances have exploited the ability to address a given disease at the underlying level of transcription and translation. These treatment paradigms utilize nucleic acids - including short interfering...
8.
Marcum J, Roberts C, Manan R, Cervarich T, Meek S
J Am Chem Soc
. 2017 Oct;
139(44):15580-15583.
PMID: 29058881
Catalytic enantioselective addition of N-heteroarenes to terminal and internal 1,3-dienes is reported. Reactions are promoted by 5 mol % of Rh catalyst supported by a new chiral pincer carbodicarbene ligand...
9.
Goldfogel M, Roberts C, Manan R, Meek S
Org Lett
. 2016 Dec;
19(1):90-93.
PMID: 27996276
Catalytic intermolecular hydroalkylation of dienes with silyloxyfuran nucleophiles is reported. Reactions are catalyzed by 5 mol % of a (CDC)-Rh complex and proceed in up to 87% yield and 6:1...
10.
Manan R, Zhao P
Nat Commun
. 2016 Jun;
7:11506.
PMID: 27321650
Catalytic C-H activation and hydroamination represent two important strategies for eco-friendly chemical synthesis with high atom efficiency and reduced waste production. Combining both C-H activation and hydroamination in a cascade...