Rajesh Bahekar
Overview
Explore the profile of Rajesh Bahekar including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
149
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Recent Articles
1.
Joshi D, Bahekar R, Soman S, Jadav P, Patel D, Goswami A, et al.
Bioorg Chem
. 2022 Nov;
130:106238.
PMID: 36403335
To discover the best-in-class Bruton's Tyrosine Kinase (BTK) inhibitors, for th treatment of autoimmune disorders like cancer (B-Cell Lymphoma (BCL)) and rheumatoid arthritis (RA), in the present investigation, novel structural...
2.
Jain M, Patel R, Prajapati K, Vyas P, Bandyopadhyay D, Prajapati V, et al.
Eur J Pharmacol
. 2022 Apr;
924:174961.
PMID: 35443192
Opioid receptor agonists are effective analgesic agents. Central activation of the mu and/or kappa opioid receptors (KOR) is associated with CNS side effects, which limits their effectiveness. Recent studies indicated...
3.
Ghoshdastidar K, Patel H, Bhayani H, Patel A, Thakkar K, Patel D, et al.
Pharmacol Res Perspect
. 2020 Aug;
8(4):e00565.
PMID: 32790160
Bruton's tyrosine kinase (BTK) plays a central and pivotal role in controlling the pathways involved in the pathobiology of cancer, rheumatoid arthritis (RA), and other autoimmune disorders. ZYBT1 is a...
4.
Patel V, Joharapurkar A, Kshirsagar S, Patel M, Savsani H, Bahekar R, et al.
Drug Res (Stuttg)
. 2020 Jul;
70(8):376-384.
PMID: 32645724
Background: Obesity and diabetes are major metabolic disorders that progress to severe morbidity and mortality. Neuroendocrine mechanisms controlling energy balance indicate that combination therapies are needed to sustain weight loss....
5.
Bahekar R, Panchal N, Soman S, Desai J, Patel D, Argade A, et al.
Bioorg Chem
. 2020 Apr;
99:103851.
PMID: 32334196
Selective inhibition of janus kinase (JAK) has been identified as an important strategy for the treatment of autoimmune disorders. Optimization at the C2 and C4-positions of pyrimidine ring of Cerdulatinib...
6.
Bahekar R, Dave B, Soman S, Patel D, Chopade R, Funde R, et al.
Bioorg Med Chem Lett
. 2019 Apr;
29(11):1313-1319.
PMID: 30975623
PI3Kδ is implicated in various inflammatory and autoimmune diseases. For the effective treatment of chronic immunological disorders such as rheumatoid arthritis, it is essential to develop isoform selective PI3Kδ inhibitors....
7.
Patel V, Joharapurkar A, Kshirsagar S, Patel M, Sutariya B, Patel H, et al.
Can J Physiol Pharmacol
. 2018 Feb;
96(6):587-596.
PMID: 29406832
Nonalcoholic fatty liver disease (NAFLD) is often associated with obesity and type 2 diabetes. Coagonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) are under clinical investigation for the...
8.
Patel V, Joharapurkar A, Kshirsagar S, Sutariya B, Patel M, Patel H, et al.
Cardiovasc Hematol Agents Med Chem
. 2018 Jan;
16(1):35-43.
PMID: 29357809
Background: Obesity, diabetes and dyslipidemica are the key pathogenic stimulus that enhances progression of Non-Alcoholic Fatty Liver Disease (NAFLD). Coagonist of Glucagon Like- Peptide-1 (GLP-1) Receptor (GLP-1R) and Glucagon Receptor...
9.
Patel V, Joharapurkar A, Kshirsagar S, Sutariya B, Patel M, Pandey D, et al.
Chem Biol Interact
. 2018 Jan;
282:13-21.
PMID: 29325849
Dyslipidemia enhances progression of atherosclerosis. Coagonist of GLP-1 and glucagon are under clinical investigation for the treatment of obesity and diabetes. Earlier, we have observed that coagonist reduced circulating and...
10.
Patel V, Joharapurkar A, Kshirsagar S, Sutariya B, Patel M, Patel H, et al.
Biomed Pharmacother
. 2017 Dec;
98:364-371.
PMID: 29275178
Coagonists of Glucagon-like peptide-1 (GLP-1) and glucagon receptors are under clinical investigation for treatment of obesity associated with diabetes. In addition to their role in glucose homeostasis, GLP-1 and glucagon...