Rajeev I Desai
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Explore the profile of Rajeev I Desai including associated specialties, affiliations and a list of published articles.
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35
Citations
489
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Recent Articles
1.
Ognibene J, Desai R, Kulkarni P, Ferris C
Front Pharmacol
. 2024 Nov;
15:1413812.
PMID: 39494344
Background: There are increasing reports of the misuse of prescription psychostimulants for cognitive enhancement together with recreational cannabis. This raises a concern that chronic use of cannabis high in Δ-THC...
2.
Yu I, Coyle J, Desai R
Nicotine Tob Res
. 2024 Jun;
26(12):1744-1748.
PMID: 38919117
Introduction: The high comorbidity between schizophrenia and cigarette smoking points to a possible shared heritable factor predisposing individuals with schizophrenia to nicotine addiction. The N-methyl-d-aspartate (NMDA) receptor has been highly...
3.
Mason C, Green J, Adamopoulos K, Afshin E, Baechle J, Basner M, et al.
Nature
. 2024 Jun;
632(8027):995-1008.
PMID: 38862027
The recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space...
4.
Burke E, Desai R
Drug Alcohol Depend
. 2024 Apr;
258:111280.
PMID: 38614019
The most prevalent psychoactive chemical in tobacco smoke is nicotine, which has been shown to maintain tobacco consumption as well as cause acute adverse effects at high doses, like nausea...
5.
Alkhelb D, Burke E, Zvonok A, Iliopoulos-Tsoutsouvas C, Georgiadis M, Jiang S, et al.
Eur J Pharmacol
. 2023 Dec;
960:176168.
PMID: 38059442
The synthetic forms of delta-9-tetrahydrocannabinol (Δ-THC), dronabinol or nabilone, have been approved to treat several indications. However, due to safety concerns their clinical utility remains limited. Consequently, there is a...
6.
Bremer P, Burke E, Barrett A, Desai R
Nat Commun
. 2023 Dec;
14(1):7700.
PMID: 38052779
The opioid crisis in the United States is primarily driven by the highly potent synthetic opioid fentanyl leading to >70,000 overdose deaths annually; thus, new therapies for fentanyl overdose are...
7.
Desai R, Kangas B, Luc O, Solakidou E, Smith E, Dawes M, et al.
Nat Commun
. 2023 Nov;
14(1):7779.
PMID: 38012180
Astronauts will encounter extended exposure to galactic cosmic radiation (GCR) during deep space exploration, which could impair brain function. Here, we report that in male mice, acute or chronic GCR...
8.
Alwood J, Mulavara A, Iyer J, Mhatre S, Rosi S, Shelhamer M, et al.
Life (Basel)
. 2023 Sep;
13(9).
PMID: 37763256
Biomarkers, ranging from molecules to behavior, can be used to identify thresholds beyond which performance of mission tasks may be compromised and could potentially trigger the activation of countermeasures. Identification...
9.
Alkhelb D, Kirunda A, Ho T, Makriyannis A, Desai R
Drug Alcohol Depend
. 2022 Oct;
240:109646.
PMID: 36191533
Evidence suggests the existence of a functional interaction between endogenous cannabinoid (CB) and opioid systems. Thus, targeting CB receptors might be a viable approach to develop new medications for opioid...
10.
Desai R, Limoli C, Stark C, Stark S
Neurosci Biobehav Rev
. 2022 Apr;
138:104676.
PMID: 35461987
The response of the human body to multiple spaceflight stressors is complex, but mounting evidence implicate risks to CNS functionality as significant, able to threaten metrics of mission success and...