Rajat M Gupta
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Explore the profile of Rajat M Gupta including associated specialties, affiliations and a list of published articles.
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38
Citations
1961
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Recent Articles
1.
Marston N, Kamanu F, Melloni G, Schnitzler G, Hakim A, Ma R, et al.
Nat Med
. 2025 Feb;
PMID: 40011692
The role of endothelial cell (EC) dysfunction in contributing to an individual's susceptibility to coronary atherosclerosis and how low-density lipoprotein cholesterol (LDL-C) concentrations might modify this relationship have not been...
2.
Hakim A, Connally N, Schnitzler G, Cho M, Jiang Z, Sunyaev S, et al.
Genes (Basel)
. 2025 Jan;
16(1).
PMID: 39858631
Low-density lipoprotein cholesterol (LDL-C) is a well-established risk factor for cardiovascular disease, and it plays a causal role in the development of atherosclerosis. Genome-wide association studies (GWASs) have successfully identified...
3.
Nazeen S, Wang X, Morrow A, Strom R, Ethier E, Ritter D, et al.
bioRxiv
. 2025 Jan;
PMID: 39829934
Gene networks encapsulate biological knowledge, often linked to polygenic diseases. While model system experiments generate many plausible gene networks, validating their role in human phenotypes requires evidence from human genetics....
4.
Amrute J, Lee P, Eres I, Lee C, Bredemeyer A, Sheth M, et al.
medRxiv
. 2024 Nov;
PMID: 39606421
Although genome wide association studies (GWAS) in large populations have identified hundreds of variants associated with common diseases such as coronary artery disease (CAD), most disease-associated variants lie within non-coding...
5.
Yu Z, Vromman A, Nguyen N, Schuermans A, Rentz T, Vellarikkal S, et al.
bioRxiv
. 2024 Nov;
PMID: 39554199
Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer novel insights into downstream clinical consequences. Here, we explore such patterns in clonal hematopoiesis of indeterminate potential...
6.
Goeva A, Dolan M, Luu J, Garcia E, Boiarsky R, Gupta R, et al.
Nat Commun
. 2024 Nov;
15(1):9468.
PMID: 39487129
In case-control single-cell RNA-seq studies, sample-level labels are transferred onto individual cells, labeling all case cells as affected, when in reality only a small fraction of them may actually be...
7.
Schnitzler G, Kang H, Fang S, Angom R, Lee-Kim V, Ma X, et al.
Nature
. 2024 Feb;
626(8000):799-807.
PMID: 38326615
Linking variants from genome-wide association studies (GWAS) to underlying mechanisms of disease remains a challenge. For some diseases, a successful strategy has been to look for cases in which multiple...
8.
Zhu Q, Hsu Y, Lassen F, MacDonald B, Stead S, Malolepsza E, et al.
Commun Biol
. 2024 Jan;
7(1):87.
PMID: 38216744
Population-based association studies have identified many genetic risk loci for coronary artery disease (CAD), but it is often unclear how genes within these loci are linked to CAD. Here, we...
9.
Pepin M, Gupta R
Am J Pathol
. 2023 Oct;
194(4):499-509.
PMID: 37827214
Endothelial cells (ECs) mediate several biological functions that are relevant to atherosclerosis and coronary artery disease (CAD), regulating an array of vital processes including vascular tone, wound healing, reactive oxygen...
10.
Weeks E, Ulirsch J, Cheng N, Trippe B, Fine R, Miao J, et al.
Nat Genet
. 2023 Jul;
55(8):1267-1276.
PMID: 37443254
Genome-wide association studies (GWASs) are a valuable tool for understanding the biology of complex human traits and diseases, but associated variants rarely point directly to causal genes. In the present...