Rajat K Das
Overview
Explore the profile of Rajat K Das including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
500
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0
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Recent Articles
1.
Chen G, Chen C, Das R, Gao P, Chen C, Bandyopadhyay S, et al.
Cancer Discov
. 2021 Apr;
11(9):2186-2199.
PMID: 33820778
The adoptive transfer of chimeric antigen receptor (CAR) T cells represents a breakthrough in clinical oncology, yet both between- and within-patient differences in autologously derived T cells are a major...
2.
Das R, OConnor R, Grupp S, Barrett D
Blood Adv
. 2020 Oct;
4(19):4653-4664.
PMID: 33002133
Engineered T-cell therapies have demonstrated impressive clinical responses in patients with hematologic malignancies. Despite this efficacy, many patients have a transient persistence of T cells, which can be correlated with...
3.
Das R, Vernau L, Grupp S, Barrett D
Cancer Discov
. 2019 Jan;
9(4):492-499.
PMID: 30630850
Translational data on chimeric antigen receptor (CAR) T-cell trials indicate that the presence of naïve T cells in the premanufacture product is important to clinical response and persistence. In anticipation...
4.
Weiden J, Voerman D, Dolen Y, Das R, van Duffelen A, Hammink R, et al.
Front Immunol
. 2018 Dec;
9:2798.
PMID: 30546367
Biomaterial-based scaffolds are promising tools for controlled immunomodulation. They can be applied as three dimensional (3D) culture systems , whereas they may be used to dictate cellular localization and exert...
5.
Das R, Herr K, Parkar A, Kubin L
Respir Physiol Neurobiol
. 2018 Nov;
260:105-113.
PMID: 30447306
Hypoglossal (XII) motoneurons are activated by type 2 receptors for serotonin (5-HT). This activation is especially strong during wakefulness which facilitates diverse motor functions of the tongue, including the maintenance...
6.
Banerjee S, Das R, Shapiro B
Mol Cell Endocrinol
. 2018 Sep;
479:27-38.
PMID: 30170181
Previously, we identified early developmental exposure to growth hormone (GH) as the requisite organizer responsible for programming the masculinization of the hepatic cytochromes P450 (CYP)-dependent drug metabolizing enzymes (Das et...
7.
Das R, Banerjee S, Shapiro B
J Endocrinol
. 2016 Dec;
232(3):377-389.
PMID: 27980003
The sexually dimorphic expression of cytochromes P450 (CYP) drug-metabolizing enzymes has been reported in all species examined. These sex differences are only expressed during adulthood and are solely regulated by...
8.
Das R, Gocheva V, Hammink R, Zouani O, Rowan A
Nat Mater
. 2015 Dec;
15(3):318-25.
PMID: 26618883
Bulk matrix stiffness has emerged as a key mechanical cue in stem cell differentiation. Here, we show that the commitment and differentiation of human mesenchymal stem cells encapsulated in physiologically...
9.
Das R, Zouani O
Biomaterials
. 2014 Apr;
35(20):5278-5293.
PMID: 24720880
Physicochemical features of a cell nanoenvironment exert important influence on stem cell behavior and include the influence of matrix elasticity and topography on differentiation processes. The presence of growth factors...
10.
Das R, Zouani O, Labrugere C, Oda R, Durrieu M
ACS Nano
. 2013 Mar;
7(4):3351-61.
PMID: 23451935
Microenvironments such as protein composition, physical features, geometry, and elasticity play important roles in stem cell lineage specification. The components of the extracellular matrix are known to subsequently assemble into...