Rainer Bischoff
Overview
Explore the profile of Rainer Bischoff including associated specialties, affiliations and a list of published articles.
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Articles
210
Citations
2663
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Recent Articles
11.
Spanov B, Baartmans B, Olaleye O, Nicolardi S, Govorukhina N, Wuhrer M, et al.
Anal Bioanal Chem
. 2023 Jan;
415(8):1505-1513.
PMID: 36693954
Trastuzumab is known to be heterogeneous in terms of charge. Stressing trastuzumab under physiological conditions (pH 7.4 and 37 °C) increases charge heterogeneity further. Separation of charge variants of stressed...
12.
Olaleye O, Spanov B, Bults P, van der Voort A, Govorukhina N, Sonke G, et al.
Drug Metab Dispos
. 2022 Nov;
51(2):249-256.
PMID: 36379709
Therapeutic proteins (TPs) are known to be heterogeneous due to modifications that occur during the production process and storage. Modifications may also occur in TPs after their administration to patients...
13.
Zhang Y, Dreyer B, Govorukhina N, Heberle A, Koncarevic S, Krisp C, et al.
Anal Chem
. 2022 Jul;
94(31):10893-10906.
PMID: 35880733
With increasing sensitivity and accuracy in mass spectrometry, the tumor phosphoproteome is getting into reach. However, the selection of quantitation techniques best-suited to the biomedical question and diagnostic requirements remains...
14.
Sleumer B, van Faassen M, Vos M, Bischoff R, Kema I, van de Merbel N
Anal Bioanal Chem
. 2022 Jul;
414(20):6187-6200.
PMID: 35838770
The human growth hormone GH1 (22 kDa) is a commonly measured biomarker for diagnosis and during treatment of growth disorders, but its quantification by ligand binding assays may be compromised...
15.
Alipour Najmi A, Bischoff R, Permentier H
Molecules
. 2022 May;
27(10).
PMID: 35630770
-dealkylation, the removal of an -alkyl group from an amine, is an important chemical transformation which provides routes for the synthesis of a wide range of pharmaceuticals, agrochemicals, bulk and...
16.
Alipour Najmi A, Jafariyeh-Yazdi E, Hadian M, Hermans J, Bischoff R, Yue J, et al.
ChemMedChem
. 2022 Mar;
17(11):e202200040.
PMID: 35303400
A novel method for the selective catalytic N-dealkylation of drug molecules on a nanoporous gold (NPG) catalyst producing valuable N-dealkylated metabolites and intermediates is described. Drug metabolites are important chemical...
17.
van de Merbel N, Olaleye O, Spanov B, Bischoff R
Bioanalysis
. 2022 Mar;
14(7):397-400.
PMID: 35249374
No abstract available.
18.
Klont F, Horvatovich P, Bowler R, van Rikxoort E, Charbonnier J, Kwiatkowski M, et al.
Respir Res
. 2022 Jan;
23(1):15.
PMID: 35073932
Background: There is a strong need for biomarkers to better characterize individuals with COPD and to take into account the heterogeneity of COPD. The blood protein sRAGE has been put...
19.
Spanov B, Aboagye V, Olaleye O, Govorukhina N, van de Merbel N, Bischoff R
Front Chem
. 2022 Jan;
9:794247.
PMID: 35047480
Asparagine deamidation and aspartic acid isomerization in the complementarity determining regions (CDRs) of monoclonal antibodies may alter their affinity to the target antigen. Trastuzumab has two hot spots for deamidation...
20.
Gupta A, Burgess J, Borghuis T, de Vries M, Kuipers J, Permentier H, et al.
Acta Biomater
. 2022 Jan;
141:209-218.
PMID: 35038586
Lung implantable devices have been widely adopted as mechanical interventions for a wide variety of pulmonary pathologies. Despite successful initial treatment, long-term efficacy can often be impacted by fibrotic or...