Raimund Hoffrogge
Overview
Explore the profile of Raimund Hoffrogge including associated specialties, affiliations and a list of published articles.
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24
Citations
169
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Recent Articles
1.
Lehmkuhl M, Keysberg C, Otte K, Noll T, Hoffrogge R
Methods Mol Biol
. 2024 Oct;
2853:155-171.
PMID: 39460920
For decades, host cell proteins (HCPs) have been investigated as putative contaminants in downstream processing of biopharmaceutical products of Chinese hamster ovary (CHO) cells. However, little is still known about...
2.
Keysberg C, Hertel O, Hoffrogge R, Reich S, Hornung N, Holzmann K, et al.
Biotechnol Bioeng
. 2023 Dec;
121(3):942-958.
PMID: 38037755
Although small extracellular vesicles (sEVs) have promising features as an emerging therapeutic format for a broad spectrum of applications, for example, blood-brain-barrier permeability, low immunogenicity, and targeted delivery, economic manufacturability...
3.
Karsten L, Goett-Zink L, Schmitz J, Hoffrogge R, Grunberger A, Kottke T, et al.
Biosensors (Basel)
. 2022 May;
12(5).
PMID: 35624572
pH-sensitive fluorescent proteins as genetically encoded pH sensors are promising tools for monitoring intra- and extracellular pH. However, there is a lack of ratiometric pH sensors, which offer a good...
4.
Romanova N, Schelletter L, Hoffrogge R, Noll T
Appl Microbiol Biotechnol
. 2022 Mar;
106(7):2569-2586.
PMID: 35312825
Chinese hamster ovary (CHO) cells are the most commonly used host cell lines for therapeutic protein production. Exposure of these cells to highly concentrated feed solution during fed-batch cultivation can...
5.
Herrmann L, Schelletter L, Hoffrogge R, Niehaus K, Rudolph V, Farr M
Mol Biol Rep
. 2022 Feb;
49(4):3213-3223.
PMID: 35122600
Background: During viral-induced myocarditis, immune cells migrate towards the site of infection and secrete proteases, which in turn can act as sheddases by cleaving extracellular domains of transmembrane proteins. We...
6.
Keysberg C, Hertel O, Schelletter L, Busche T, Sochart C, Kalinowski J, et al.
Appl Microbiol Biotechnol
. 2021 May;
105(9):3673-3689.
PMID: 33937930
In biopharmaceutical production, Chinese hamster ovary (CHO) cells derived from Cricetulus griseus remain the most commonly used host cell for recombinant protein production, especially antibodies. Over the last decade, in-depth...
7.
A positive pressure workstation for semi-automated peptide purification of complex proteomic samples
Schelletter L, Hertel O, Antar S, Scherling C, Lattig J, Noll T, et al.
Rapid Commun Mass Spectrom
. 2020 Jun;
35(2):e8873.
PMID: 32583429
Rationale: High-throughput reliable data generation has become a substantial requirement in many "omics" investigations. In proteomics the sample preparation workflow consists of multiple steps adding more bias to the sample...
8.
Schelletter L, Albaum S, Walter S, Noll T, Hoffrogge R
Appl Microbiol Biotechnol
. 2019 Aug;
103(19):8127-8143.
PMID: 31420692
Chinese hamster ovary (CHO) cells are commonly used for the production of monoclonal antibodies. Omics technologies have been used to elucidate cellular switch points which result in higher monoclonal antibody...
9.
Wippermann A, Rupp O, Brinkrolf K, Hoffrogge R, Noll T
J Biotechnol
. 2016 Nov;
257:150-161.
PMID: 27890772
The cellular mechanisms responsible for the versatile properties of CHO cells as the major production cell line for biopharmaceutical molecules are not entirely understood yet, although several 'omics' data facilitate...
10.
Brandenbusch C, Glonke S, Collins J, Hoffrogge R, Grunwald K, Buhler B, et al.
Biotechnol Bioeng
. 2015 May;
112(11):2316-23.
PMID: 26012371
The formation of stable emulsions in biphasic biotransformations catalyzed by microbial cells turned out to be a major hurdle for industrial implementation. Recently, a cost-effective and efficient downstream processing approach,...