Raimar Lobenberg
Overview
Explore the profile of Raimar Lobenberg including associated specialties, affiliations and a list of published articles.
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132
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1256
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Recent Articles
1.
de Assis Ramos M, Ricardo-da-Silva F, Macedo L, Correia C, Moreira L, Lobenberg R, et al.
J Pharm Pharm Sci
. 2024 Dec;
27:13633.
PMID: 39619127
17β-estradiol (E2) is an endogenous steroid hormone pivotal for the development of female secondary sexual characteristics and the maintenance of the female reproductive system. Its roles extend beyond these physiological...
2.
Yousef M, Yanez J, Lobenberg R, Davies N
Biomedicines
. 2024 Aug;
12(8).
PMID: 39200307
The law of superposition underpins first-order linear pharmacokinetic relationships. Most drugs, therefore, after a single dose can be described by first-order or linear processes, which can be superposed to understand...
3.
Yousef M, Park C, Chacra N, Davies N, Lobenberg R
AAPS PharmSciTech
. 2024 Aug;
25(6):187.
PMID: 39143365
Conventional dissolution tests only assess the aqueous release of drugs to ensure quality and performance, without indicating whether absorption occurs through the portal or the lymphatic circulation. To address this...
4.
Yousef M, Bou-Chacra N, Lobenberg R, Davies N
J Pharmacol Toxicol Methods
. 2024 Aug;
129:107548.
PMID: 39098619
Scientists have developed and employed various models to investigate intestinal lymphatic uptake. One approach involves using specific blocking agents to influence the chylomicron-mediated lymphatic absorption of drugs. Currently utilized models...
5.
Yousef M, OCroinin C, Le T, Park C, Zuo J, Chacra N, et al.
Pharmaceutics
. 2024 Jun;
16(6).
PMID: 38931889
Drug absorption via chylomicrons holds significant implications for both pharmacokinetics and pharmacodynamics. However, a mechanistic understanding of predicting in vivo intestinal lymphatic uptake remains largely unexplored. This study aimed to...
6.
de Souza A, Scarim C, Cotrim P, Junior F, Rocha B, Augusto Calixto L, et al.
Nanomedicine (Lond)
. 2024 Jan;
19(4):293-301.
PMID: 38270378
Leishmaniasis, caused by the protozoan sp., infects phagocyte cells present in lymphatic organs. This study demonstrates the influence of nanostructured lipid carrier-loaded hydroxymethylnitrofurazone (NLC-NFOH) on lymphatic uptake using a chylomicron-blocking...
7.
Park C, Zuo J, Gil M, Lobenberg R, Lee B
Pharmaceutics
. 2023 Nov;
15(11).
PMID: 38004513
This study aimed to investigate the enhancement of cannabinoid acid solubility and stability through the formation of a cannabinoid acid/cyclodextrin (CD) inclusion complex. Two cannabinoid acids, tetrahydro-cannabinolic acid (THCA) and...
8.
Development of a Novel In Vitro Model to Study Lymphatic Uptake of Drugs via Artificial Chylomicrons
Yousef M, Park C, Henostroza M, Chacra N, Davies N, Lobenberg R
Pharmaceutics
. 2023 Nov;
15(11).
PMID: 38004512
The lymphatic system plays a crucial role in the absorption of lipophilic drugs, making it an important route for drug delivery. In this study, an in vitro model using Intralipid...
9.
OCroinin C, Le T, Doschak M, Lobenberg R, Davies N
J Pharm Biomed Anal
. 2023 Aug;
235:115631.
PMID: 37586306
A selective and sensitive liquid chromatography mass spectrometry assay was developed for the detection of cannflavin A, B, and C in hemp extract specimens. A deuterated analog cannabidiol-D3 was used...
10.
OCroinin C, Guerra A, Doschak M, Lobenberg R, Davies N
Pharmaceutics
. 2023 Jul;
15(7).
PMID: 37514127
is a plant used for recreational and therapeutic purposes; however, many of the secondary metabolites in the plant have not been thoroughly investigated. Stilbenes are a class of compounds with...