Rahul Sarpeshkar
Overview
Explore the profile of Rahul Sarpeshkar including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
393
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Recent Articles
1.
Zhao H, Sarpeshkar R, Mandal S
IEEE Trans Circuits Syst I Regul Pap
. 2024 Aug;
70(1):3-16.
PMID: 39157673
This paper describes an adaptive noise generator circuit suitable for on-chip simulations of stochastic chemical kinetics. The circuit uses amplified BJT white noise and adaptive low-pass filtering to emulate the...
2.
Beahm D, Deng Y, DeAngelo T, Sarpeshkar R
IEEE Trans Mol Biol Multiscale Commun
. 2023 Jul;
9(1):28-48.
PMID: 37397625
Electronic circuits intuitively visualize and quantitatively simulate biological systems with nonlinear differential equations that exhibit complicated dynamics. Drug cocktail therapies are a powerful tool against diseases that exhibit such dynamics....
3.
Deng Y, Beahm D, Ran X, Riley T, Sarpeshkar R
Front Bioeng Biotechnol
. 2022 Oct;
10:947508.
PMID: 36246369
Kinetic modeling has relied on using a tedious number of mathematical equations to describe molecular kinetics in interacting reactions. The long list of differential equations with associated abstract variables and...
4.
Beahm D, Deng Y, Riley T, Sarpeshkar R
IEEE Nanotechnol Mag
. 2022 Mar;
15(6):41-53.
PMID: 35242267
Boltzmann-exponential thermodynamic laws govern noisy molecular flux in chemical reactions as well as noisy subthreshold electron current flux in transistors. These common mathematical laws enable one to map and simulate...
5.
Deng Y, Beahm D, Ionov S, Sarpeshkar R
BMC Biol
. 2021 May;
19(1):101.
PMID: 34001118
Background: Adenosine triphosphate (ATP) is the main energy carrier in living organisms, critical for metabolism and essential physiological processes. In humans, abnormal regulation of energy levels (ATP concentration) and power...
6.
Teo J, Sarpeshkar R
iScience
. 2020 Nov;
23(11):101688.
PMID: 33163942
Biological circuits and systems within even a single cell need to be represented by large-scale feedback networks of nonlinear, stochastic, stiff, asynchronous, non-modular coupled differential equations governing complex molecular interactions....
7.
Medley J, Teo J, Woo S, Hellerstein J, Sarpeshkar R, Sauro H
PLoS Comput Biol
. 2020 Sep;
16(9):e1008063.
PMID: 32966274
The explosive growth in semiconductor integrated circuits was made possible in large part by design automation software. The design and/or analysis of synthetic and natural circuits in living cells could...
8.
Kleinfeld D, Luan L, Mitra P, Robinson J, Sarpeshkar R, Shepard K, et al.
Neuron
. 2019 Sep;
103(6):1005-1015.
PMID: 31495645
The classic approach to measure the spiking response of neurons involves the use of metal electrodes to record extracellular potentials. Starting over 60 years ago with a single recording site,...
9.
Zeng J, Banerjee A, Kim J, Deng Y, Chapman T, Daniel R, et al.
Sci Rep
. 2019 May;
9(1):7275.
PMID: 31086248
As the fields of biotechnology and synthetic biology expand, cheap and sensitive tools are needed to measure increasingly complicated genetic circuits. In order to bypass some drawbacks of optical fluorescent...
10.
Teo J, Weiss R, Sarpeshkar R
IEEE Trans Biomed Circuits Syst
. 2019 Mar;
13(3):540-553.
PMID: 30908238
Tissue homeostasis (feedback control) is an important mechanism that regulates the population of different cell types within a tissue. In type-1 diabetes, auto-immune attack and consequent death of pancreatic β...