Rahul K Das
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Explore the profile of Rahul K Das including associated specialties, affiliations and a list of published articles.
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18
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1334
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Recent Articles
11.
Das R, Ruff K, Pappu R
Curr Opin Struct Biol
. 2015 Apr;
32:102-12.
PMID: 25863585
Intrinsically disordered proteins (IDPs) showcase the importance of conformational plasticity and heterogeneity in protein function. We summarize recent advances that connect information encoded in IDP sequences to their conformational properties...
12.
Lyle N, Das R, Pappu R
J Chem Phys
. 2013 Oct;
139(12):121907.
PMID: 24089719
Conformational heterogeneity is a defining characteristic of proteins. Intrinsically disordered proteins (IDPs) and denatured state ensembles are extreme manifestations of this heterogeneity. Inferences regarding globule versus coil formation can be...
13.
Das R, Pappu R
Proc Natl Acad Sci U S A
. 2013 Aug;
110(33):13392-7.
PMID: 23901099
The functions of intrinsically disordered proteins (IDPs) are governed by relationships between information encoded in their amino acid sequences and the ensembles of conformations that they sample as autonomous units....
14.
Das R, Mittal A, Pappu R
Bioessays
. 2012 Nov;
35(1):17-22.
PMID: 23138868
N-type inactivation of potassium channels is controlled by cytosolic loops that are intrinsically disordered. Recent experiments have shown that the mechanism of N-type inactivation through disordered regions can be stereospecific...
15.
Das R, Mao A, Pappu R
Sci Signal
. 2012 Apr;
5(220):pe17.
PMID: 22510467
Eukaryotic proteins often possess long stretches that fail to adopt well-defined, three-dimensional structures. These intrinsically disordered regions are associated with cell signaling through the enrichment of hub proteins of networks...
16.
Das R, Crick S, Pappu R
J Mol Biol
. 2012 Jan;
416(2):287-99.
PMID: 22226835
Basic region leucine zippers (bZIPs) are modular transcription factors that play key roles in eukaryotic gene regulation. The basic regions of bZIPs (bZIP-bRs) are necessary and sufficient for DNA binding...
17.
Driver J, Rogers A, Jamison D, Das R, Kolomeisky A, Diehl M
Phys Chem Chem Phys
. 2010 Jun;
12(35):10398-405.
PMID: 20582368
Transport of intracellular cargos by multiple microtubule motor proteins is believed to be a common and significant phenomenon in vivo, yet signatures of the microscopic dynamics of multiple motor systems...
18.
Das R, Kolomeisky A
Phys Chem Chem Phys
. 2010 May;
12(12):2999-3004.
PMID: 20449392
A starting point of many biological processes is protein binding to specific regions on DNA. Although typical concentrations of DNA-binding proteins are low, and target sites are typically buried among...