Raffael Schaffrath
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Explore the profile of Raffael Schaffrath including associated specialties, affiliations and a list of published articles.
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77
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1395
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Recent Articles
1.
Kaduhr L, Mayer K, Schaffrath R, Buchner J, Brinkmann U
FEBS Lett
. 2025 Jan;
PMID: 39825589
The diphthamide modification of eukaryotic translation elongation factor (eEF2) is important for accurate protein synthesis. While the enzymes for diphthamide synthesis are known, coordination of eEF2 synthesis with the diphthamide...
2.
Abbassi N, Jaciuk M, Scherf D, Bohnert P, Rau A, Hammermeister A, et al.
Nat Commun
. 2024 May;
15(1):4094.
PMID: 38750017
tRNA modifications affect ribosomal elongation speed and co-translational folding dynamics. The Elongator complex is responsible for introducing 5-carboxymethyl at wobble uridine bases (cmU) in eukaryotic tRNAs. However, the structure and...
3.
Gorlitz K, Bessler L, Helm M, Schaffrath R, Klassen R
Nucleic Acids Res
. 2024 May;
52(10):5841-5851.
PMID: 38716877
Therapeutic fluoropyrimidines 5-fluorouracil (5-FU) and 5-fluorocytosine (5-FC) are in long use for treatment of human cancers and severe invasive fungal infections, respectively. 5-Fluorouridine triphosphate represents a bioactive metabolite of both...
4.
Jun S, Cho K, Schaffrath R, Kim G
Int J Mol Sci
. 2024 Apr;
25(8).
PMID: 38673955
The Elongator complex plays a pivotal role in the wobble uridine modification of the tRNA anticodon. Comprising two sets of six distinct subunits, namely, Elongator proteins (ELP1-ELP6) and associated proteins,...
5.
Utkur K, Mayer K, Liu S, Brinkmann U, Schaffrath R
Biomolecules
. 2024 Apr;
14(4).
PMID: 38672486
The Dph1•Dph2 heterodimer from yeast is a radical SAM (RS) enzyme that generates the 3-amino-3-carboxy-propyl (ACP) precursor for diphthamide, a clinically relevant modification on eukaryotic elongation factor 2 (eEF2). ACP...
6.
Antas P, Cleveland A, Contessotto P, Schaffrath R
Trends Mol Med
. 2024 Jan;
30(2):107-109.
PMID: 38272715
No abstract available.
7.
Schaffrath R, Brinkmann U
Trends Mol Med
. 2023 Dec;
30(2):164-177.
PMID: 38097404
Diphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis are conserved in eukaryotes and archaea. Originally identified...
8.
Utkur K, Schmidt S, Mayer K, Klassen R, Brinkmann U, Schaffrath R
Biomolecules
. 2023 Nov;
13(11).
PMID: 38002337
In eukaryotes, the Dph1•Dph2 dimer is a non-canonical radical SAM enzyme. Using iron-sulfur (FeS) clusters, it cleaves the cosubstrate S-adenosyl-methionine (SAM) to form a 3-amino-3-carboxy-propyl (ACP) radical for the synthesis...
9.
Helm M, Bohnsack M, Carell T, Dalpke A, Entian K, Ehrenhofer-Murray A, et al.
ACS Chem Biol
. 2023 Nov;
18(12):2441-2449.
PMID: 37962075
The chemical biology of native nucleic acid modifications has seen an intense upswing, first concerning DNA modifications in the field of epigenetics and then concerning RNA modifications in a field...
10.
Matos G, Vogt L, Santos R, Devillars A, Yoshinaga M, Miyamoto S, et al.
Mol Microbiol
. 2023 Oct;
120(6):893-905.
PMID: 37864403
In the yeast Saccharomyces cerevisiae, the absence of the pseudouridine synthase Pus3/Deg1, which modifies tRNA positions 38 and 39, results in increased lipid droplet (LD) content and translational defects. In...