Rafael Leon
Overview
Explore the profile of Rafael Leon including associated specialties, affiliations and a list of published articles.
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Articles
89
Citations
1621
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Recent Articles
1.
Cuadrado A, Cazalla E, Bach A, Bathish B, Naidu S, DeNicola G, et al.
Redox Biol
. 2025 Mar;
:103569.
PMID: 40059038
Nuclear factor erythroid 2-related factor 2 (NRF2) is a redox-activated transcription factor regulating cellular defense against oxidative stress, thereby playing a pivotal role in maintaining cellular homeostasis. Its dysregulation is...
2.
Duarte P, Sanchez-Porro F, Crisman E, Cores A, Jimenez I, Cuadrado A, et al.
J Med Chem
. 2025 Jan;
68(3):3495-3517.
PMID: 39818855
Parkinson's disease (PD), the second most common neurodegenerative disorder, affects around 10 million people worldwide. It is a multifactorial disease marked by dopaminergic neuron loss with oxidative stress (OS) and...
3.
Rodriguez-Gomez J, Gracia-Ahufinger I I, Carmona-Flores R, Guzman-Puche J, Leon R, Perez-Nadales E, et al.
J Glob Antimicrob Resist
. 2024 Dec;
41:138-143.
PMID: 39736428
Objective: To evaluate the efficacy of high-dose intravenous fosfomycin for the treatment of urinary tract infections (UTI) caused by KPC carbapenemase-producing Klebsiella pneumoniae (KPC-Kp). A secondary objective was to evaluate...
4.
Herrera-Arozamena C, Estrada-Valencia M, Garcia-Diez G, Perez C, Leon R, Infantes L, et al.
Eur J Med Chem
. 2024 Aug;
277:116763.
PMID: 39146834
5-Methoxy-3-(5-methoxyindolin-2-yl)-1H-indole (3), whose structure was unambiguously elucidated by X-ray analysis, was identified as a multi-target compound with potential application in neurodegenerative diseases. It is a low nanomolar inhibitor of QR2...
5.
Marti-Andres P, Finamor I, Torres-Cuevas I, Perez S, Rius-Perez S, Colino-Lage H, et al.
EMBO J
. 2024 May;
43(13):2789-2812.
PMID: 38811853
It has remained unknown how cells reduce cystine taken up from the extracellular space, which is a required step for further utilization of cysteine in key processes such as protein...
6.
Mayo P, Pascual J, Crisman E, Dominguez C, Lopez M, Leon R
Med Res Rev
. 2024 Apr;
44(6):2367-2419.
PMID: 38678582
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and is a major health threat globally. Its prevalence is forecasted to exponentially increase during the next 30 years due to...
7.
Millan-Becerro R, Leon R, Romero-Matos J, Moreno-Gonzalez R, Perez-Lopez R
Sci Total Environ
. 2024 Mar;
922:171341.
PMID: 38448308
No abstract available.
8.
Martinez-Casales M, Hernanz R, Gonzalez-Carnicero Z, Barrus M, Martin A, Briones A, et al.
J Pharmacol Exp Ther
. 2023 Dec;
388(2):670-687.
PMID: 38129126
Inflammatory mechanisms and oxidative stress seem to contribute to the pathogenesis of hypertension. ITH13001 is a melatonin-phenyl-acrylate hybrid that moderately induces the antioxidant transcription factor Nrf2 (nuclear factor erythroid 2-related...
9.
Millan-Becerro R, Leon R, Romero-Matos J, Moreno-Gonzalez R, Perez-Lopez R
Sci Total Environ
. 2023 Dec;
912:169379.
PMID: 38114405
No abstract available.
10.
Millan-Becerro R, Leon R, Romero-Matos J, Moreno-Gonzalez R, Perez-Lopez R
Sci Total Environ
. 2023 Oct;
907:168078.
PMID: 37898213
No abstract available.