Rafael A Rosales
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Explore the profile of Rafael A Rosales including associated specialties, affiliations and a list of published articles.
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11
Citations
423
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Recent Articles
1.
Valieris R, Martins L, Defelicibus A, Bueno A, Osorio C, Carraro D, et al.
Breast Cancer Res
. 2024 Aug;
26(1):124.
PMID: 39160593
Background: Human epidermal growth factor receptor 2 (HER2)-low breast cancer has emerged as a new subtype of tumor, for which novel antibody-drug conjugates have shown beneficial effects. Assessment of HER2...
2.
Sutcliffe S, Kraemer S, Ellmen I, Knapp J, Overton A, Nash D, et al.
Microb Genom
. 2024 May;
10(5).
PMID: 38785221
Wastewater-based surveillance (WBS) is an important epidemiological and public health tool for tracking pathogens across the scale of a building, neighbourhood, city, or region. WBS gained widespread adoption globally during...
3.
Drummond R, Defelicibus A, Meyenberg M, Valieris R, Dias-Neto E, Rosales R, et al.
BMC Bioinformatics
. 2023 Nov;
24(1):439.
PMID: 37990302
Background: Cancer is a collection of diseases caused by the deregulation of cell processes, which is triggered by somatic mutations. The search for patterns in somatic mutations, known as mutational...
4.
Valieris R, Drummond R, Defelicibus A, Dias-Neto E, Rosales R, Tojal Da Silva I
Bioinformatics
. 2022 Feb;
38(7):1809-1815.
PMID: 35104309
Motivation: Despite of the fast development of highly effective vaccines to control the current COVID-19 pandemics, the unequal distribution and availability of these vaccines worldwide and the number of people...
5.
Rosales R, Drummond R, Valieris R, Dias-Neto E, da Silva I
Bioinformatics
. 2016 Sep;
33(1):8-16.
PMID: 27591080
Motivation: Mutational signatures can be used to understand cancer origins and provide a unique opportunity to group tumor types that share the same origins and result from similar processes. These...
6.
Cohn L, Silva I, Oliveira T, Rosales R, Parrish E, Learn G, et al.
Cell
. 2015 Jan;
160(3):420-32.
PMID: 25635456
The barrier to curing HIV-1 is thought to reside primarily in CD4(+) T cells containing silent proviruses. To characterize these latently infected cells, we studied the integration profile of HIV-1...
7.
Silva I, Rosales R, Holanda A, Nussenzweig M, Jankovic M
Bioinformatics
. 2014 May;
30(18):2551-8.
PMID: 24860160
Motivation: The detection of genomic regions unusually rich in a given pattern is an important undertaking in the analysis of next-generation sequencing data. Recent studies of chromosomal translocations in activated...
8.
Rosales R, Varanda W
Biophys J
. 2009 May;
96(10):3987-96.
PMID: 19450470
Large-conductance Ca(2+)-activated K(+) channels (BK) play a fundamental role in modulating membrane potential in many cell types. The gating of BK channels and its modulation by Ca(2+) and voltage has...
9.
Rosales R
Bull Math Biol
. 2004 Aug;
66(5):1173-99.
PMID: 15294422
This paper is concerned with the statistical analysis of single ion channel records. Single channels are modelled by using hidden Markov models and a combination of Bayesian statistics and Markov...
10.
Rosales R, Fill M, Escobar A
J Gen Physiol
. 2004 Apr;
123(5):533-53.
PMID: 15111644
Type-II ryanodine receptor channels (RYRs) play a fundamental role in intracellular Ca(2+) dynamics in heart. The processes of activation, inactivation, and regulation of these channels have been the subject of...