Radim Vrzal
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Explore the profile of Radim Vrzal including associated specialties, affiliations and a list of published articles.
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73
Citations
640
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Recent Articles
1.
Vrzalova A, Vrzal R, Nadvornik P, Sebela M, Dvorak Z
Bioorg Med Chem
. 2024 Oct;
114:117964.
PMID: 39454560
The aryl hydrocarbon receptor (AhR) is a cytosolic ligand-activated transcription factor integral to various physiological and pathological processes. Among its diverse ligands, indole-based compounds have garnered attention due to their...
2.
Vrzalova A, Vrzal R
Biochimie
. 2024 Sep;
228:138-157.
PMID: 39321911
Plasminogen activator inhibitor 1 (PAI-1) is a crucial serine protease inhibitor that prevents plasminogen activation by inhibiting tissue- and urokinase-type plasminogen activators (tPA, uPA). PAI-1 is well-known for its role...
3.
Vrzal R, Marcalikova A, Krasulova K, Zemankova L, Dvorak Z
Int J Mol Sci
. 2023 Nov;
24(21).
PMID: 37958638
Herbal extracts represent a wide spectrum of biologically active ingredients with potential medical applications. By screening minor constituents of jasmine essential oil towards aryl hydrocarbon receptor (AhR) activity using a...
4.
Sladekova L, Zgarbova E, Vrzal R, Vanda D, Soural M, Jakubcova K, et al.
Toxicol Lett
. 2023 Oct;
387:63-75.
PMID: 37778463
Microbial indoles have been demonstrated as selective or dual agonists and ligands of the pregnane X receptor (PXR) and aryl hydrocarbon receptor (AhR). However, structural determinants of microbial indoles selectivity...
5.
Ondrova K, Zuvalova I, Vyhlidalova B, Krasulova K, Mikova E, Vrzal R, et al.
Nat Commun
. 2023 May;
14(1):2728.
PMID: 37169746
The human aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is a pivotal regulator of human physiology and pathophysiology. Allosteric inhibition of AhR was previously thought to be...
6.
Zgarbova E, Vrzal R
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36613955
The activation of the aryl hydrocarbon receptor (AhR) by xenobiotic compounds was demonstrated to result in the degradation of the androgen receptor (AR). Since prostate cancer is often dependent on...
7.
Zgarbova E, Vrzal R
Biochimie
. 2022 Dec;
208:1-12.
PMID: 36586563
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and is produced by certain flowers. Skatole has been used in specific products of the perfume industry...
8.
Imran S, Vagaska B, Kriska J, Anderova M, Bortolozzi M, Gerosa G, et al.
Pharmaceuticals (Basel)
. 2022 Jul;
15(7).
PMID: 35890127
Exposure to environmental pollutants and endogenous metabolites that induce aryl hydrocarbon receptor (AhR) expression has been suggested to affect cognitive development and, particularly in boys, also motor function. As current...
9.
Grycova A, Joo H, Maier V, Illes P, Vyhlidalova B, Poulikova K, et al.
J Med Chem
. 2022 Apr;
65(9):6859-6868.
PMID: 35416668
Targeting the aryl hydrocarbon receptor (AhR) is an emerging therapeutic strategy for multiple diseases (e.g., inflammatory bowel disease). microbial metabolite 2-(1'-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) is a putative AhR endogenous...
10.
Pavek P, Dusek J, Smutny T, Lochman L, Kucera R, Skoda J, et al.
Mol Nutr Food Res
. 2022 Feb;
66(9):e2200070.
PMID: 35184385
Scope: CYP3A4 is the most important drug-metabolizing enzyme regulated via the vitamin D receptor (VDR) in the intestine. However, less is known about VDR in the regulation of CYP3A4 and...