Rachel E Thomson
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Explore the profile of Rachel E Thomson including associated specialties, affiliations and a list of published articles.
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16
Citations
578
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Recent Articles
1.
Saunders A, Thomson R, Goodman C, Anderson R, Gregorevic P
Cancer Metastasis Rev
. 2024 Jul;
43(4):1511-1527.
PMID: 38995522
Many organs of the body are susceptible to cancer development. However, striated muscles-which include skeletal and cardiac muscles-are rarely the sites of primary cancers. Most deaths from cancer arise due...
2.
Sartori R, Hagg A, Zampieri S, Armani A, Winbanks C, Viana L, et al.
Sci Transl Med
. 2021 Aug;
13(605).
PMID: 34349036
Most patients with advanced solid cancers exhibit features of cachexia, a debilitating syndrome characterized by progressive loss of skeletal muscle mass and strength. Because the underlying mechanisms of this multifactorial...
3.
Hagg A, Kharoud S, Goodchild G, Goodman C, Chen J, Thomson R, et al.
Front Physiol
. 2020 Nov;
11:560225.
PMID: 33250771
Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting propeptides and antibodies, or follistatin can increase skeletal muscle mass in healthy mice and ameliorate...
4.
Davey J, Estevez E, Thomson R, Whitham M, Watt K, Hagg A, et al.
FASEB J
. 2020 Mar;
34(4):5697-5714.
PMID: 32141144
Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating pancreatic β-cell function. The pro-inflammatory factor Activin has been implicated as a positive correlate...
5.
Winbanks C, Murphy K, Bernardo B, Qian H, Liu Y, Sepulveda P, et al.
Sci Transl Med
. 2016 Jul;
8(348):348ra98.
PMID: 27440729
Patients with advanced cancer often succumb to complications arising from striated muscle wasting associated with cachexia. Excessive activation of the type IIB activin receptor (ActRIIB) is considered an important mechanism...
6.
Hagg A, Colgan T, Thomson R, Qian H, Lynch G, Gregorevic P
Sci Rep
. 2016 Mar;
6:23042.
PMID: 26972746
Anabolic β2-adrenoceptor (β2-AR) agonists have been proposed as therapeutics for treating muscle wasting but concerns regarding possible off-target effects have hampered their use. We investigated whether β2-AR-mediated signalling could be...
7.
Sepulveda P, Lamon S, Hagg A, Thomson R, Winbanks C, Qian H, et al.
Sci Rep
. 2015 Dec;
5:17535.
PMID: 26657343
Follistatin is an inhibitor of TGF-β superfamily ligands that repress skeletal muscle growth and promote muscle wasting. Accordingly, follistatin has emerged as a potential therapeutic to ameliorate the deleterious effects...
8.
Chen J, Walton K, Winbanks C, Murphy K, Thomson R, Makanji Y, et al.
FASEB J
. 2014 Jan;
28(4):1711-23.
PMID: 24378873
In models of cancer cachexia, inhibiting type IIB activin receptors (ActRIIBs) reverse muscle wasting and prolongs survival, even with continued tumor growth. ActRIIB mediates signaling of numerous TGF-β proteins; of...
9.
Winbanks C, Chen J, Qian H, Liu Y, Bernardo B, Beyer C, et al.
J Cell Biol
. 2013 Oct;
203(2):345-57.
PMID: 24145169
Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway...
10.
Winbanks C, Weeks K, Thomson R, Sepulveda P, Beyer C, Qian H, et al.
J Cell Biol
. 2012 Jun;
197(7):997-1008.
PMID: 22711699
Follistatin is essential for skeletal muscle development and growth, but the intracellular signaling networks that regulate follistatin-mediated effects are not well defined. We show here that the administration of an...