Rachael E Ford
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Explore the profile of Rachael E Ford including associated specialties, affiliations and a list of published articles.
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6
Citations
101
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Recent Articles
1.
Elsen N, Patel S, Ford R, Hall D, Hess F, Kandula H, et al.
Nat Chem Biol
. 2017 Mar;
13(6):613-615.
PMID: 28346407
O-GlcNAc hydrolase (OGA) catalyzes removal of βα-linked N-acetyl-D-glucosamine from serine and threonine residues. We report crystal structures of Homo sapiens OGA catalytic domain in apo and inhibited states, revealing a...
2.
Kutilek V, Andrews C, Richards M, Xu Z, Sun T, Chen Y, et al.
J Biomol Screen
. 2016 Mar;
21(6):608-19.
PMID: 26969322
The primary objective of early drug discovery is to associate druggable target space with a desired phenotype. The inability to efficiently associate these often leads to failure early in the...
3.
Allen S, Parthasarathy G, Darke P, Diehl R, Ford R, Hall D, et al.
J Biol Chem
. 2015 Jul;
290(33):20360-73.
PMID: 26134571
G-protein-coupled receptor (GPCR) kinases (GRKs) bind to and phosphorylate GPCRs, initiating the process of GPCR desensitization and internalization. GRK4 is implicated in the regulation of blood pressure, and three GRK4...
4.
Rickert K, Patel S, Allison T, Byrne N, Darke P, Ford R, et al.
J Biol Chem
. 2011 Jan;
286(13):11218-25.
PMID: 21247903
The receptor tyrosine kinase c-Met is implicated in oncogenesis and is the target for several small molecule and biologic agents in clinical trials for the treatment of cancer. Binding of...
5.
Soisson S, Patel S, Abeywickrema P, Byrne N, Diehl R, Hall D, et al.
BMC Struct Biol
. 2010 Jun;
10:16.
PMID: 20540760
Background: The unique S28 family of proteases is comprised of the carboxypeptidase PRCP and the aminopeptidase DPP7. The structural basis of the different substrate specificities of the two enzymes is...
6.
Abeywickrema P, Patel S, Byrne N, Diehl R, Hall D, Ford R, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2010 Jun;
66(Pt 6):702-5.
PMID: 20516604
Prolylcarboxypeptidase (PrCP) is a lysosomal serine carboxypeptidase that cleaves a variety of C-terminal amino acids adjacent to proline and has been implicated in diseases such as hypertension and obesity. Here,...