R Z Sterzycki
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Explore the profile of R Z Sterzycki including associated specialties, affiliations and a list of published articles.
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4
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36
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Recent Articles
1.
Sterzycki R, Ghazzouli I, Brankovan V, Martin J, Mansuri M
J Med Chem
. 1990 Aug;
33(8):2150-7.
PMID: 2165162
Several 2'-fluoroarabino-2',3'-dideoxy- and 2'-fluoro-2',3'-unsaturated 2',3'-dideoxy pyrimidine nucleoside analogues are reported. The saturated analogues 1-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)thymine (2'-threo-FddT, 33), 1-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)uracil (2'-threo-FddU, 22) were readily prepared from the corresponding 2'-deoxy-2'-fluoroarabinosyl nucleoside analogue by radical...
2.
Mansuri M, Hitchcock M, Buroker R, Bregman C, Ghazzouli I, Desiderio J, et al.
Antimicrob Agents Chemother
. 1990 Apr;
34(4):637-41.
PMID: 1693057
Three analogs of thymidine, D4T [2',3'-didehydro-2',3'-dideoxythymidine; 1-(2,3-dideoxy-beta-D-glyceropent-2-enofuranosyl)thymine], FddT (3'-fluoro-3'-deoxythymidine), and AZT (3'-azido-3'-deoxythymidine), were compared in biological tests designed to assess their potential utility as anti-human immunodeficiency virus (HIV) agents. The...
3.
Martin J, Hitchcock M, Fridland A, Ghazzouli I, Kaul S, Dunkle L, et al.
Ann N Y Acad Sci
. 1990 Jan;
616:22-8.
PMID: 1964029
No abstract available.
4.
Mansuri M, Starrett Jr J, Ghazzouli I, Hitchcock M, Sterzycki R, Brankovan V, et al.
J Med Chem
. 1989 Feb;
32(2):461-6.
PMID: 2536441
The nucleoside analogue 1-(2,3-dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine (d4T, 1) was prepared by ring opening of the 3',5'-anhydro compound 5. This method has been refined such that it can be used to prepare d4T...