R W Schevitz
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Explore the profile of R W Schevitz including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
874
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Recent Articles
1.
Jin L, Briggs S, Chandrasekhar S, Chirgadze N, CLAWSON D, Schevitz R, et al.
J Biol Chem
. 2000 Jun;
275(35):27238-44.
PMID: 10837469
The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered intermittently, results in increased bone formation in patients with osteoporosis. PTH and a related molecule, parathyroid hormone-related peptide (PTHrP), act on...
2.
Chirgadze N, Sall D, Briggs S, CLAWSON D, Zhang M, Smith G, et al.
Protein Sci
. 2000 Mar;
9(1):29-36.
PMID: 10739244
The crystal structures of four active site-directed thrombin inhibitors, 1-4, in a complex with human alpha-thrombin have been determined and refined at up to 2.0 A resolution using X-ray crystallography....
3.
Mihelich E, Schevitz R
Biochim Biophys Acta
. 1999 Nov;
1441(2-3):223-8.
PMID: 10570250
Human non-pancreatic secretory phospholipase A(2) (hnps-PLA(2)) is a group IIA enzyme that is massively over-expressed in a variety of severe inflammatory diseases. The enzyme degrades membrane phospholipids and it has...
4.
Wery J, Schevitz R
Curr Opin Chem Biol
. 1998 Jul;
1(3):365-9.
PMID: 9667874
Advances in experimental and computational techniques have reaffirmed the role of protein X-ray crystallography as one of the primary providers of structural information both to enhance our fundamental understanding of...
5.
Zhang F, Basinski M, Beals J, Briggs S, Churgay L, CLAWSON D, et al.
Nature
. 1997 May;
387(6629):206-9.
PMID: 9144295
Mutations in the obese gene (OB) or in the gene encoding the OB receptor(OB-R) result in obesity, infertility and diabetes in a variety of mouse phenotypes. The demonstration that OB...
6.
DILLARD R, Bach N, Draheim S, Berry D, Carlson D, Chirgadze N, et al.
J Med Chem
. 1996 Dec;
39(26):5119-36.
PMID: 9005255
Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been...
7.
Draheim S, Bach N, DILLARD R, Berry D, Carlson D, Chirgadze N, et al.
J Med Chem
. 1996 Dec;
39(26):5159-75.
PMID: 8978844
The preceding papers of this series detail the development of functionalized indole-3-acetamides as inhibitors of hnps-PLA2. We describe here the extension of the structure-activity relationship to include a series of...
8.
DILLARD R, Bach N, Draheim S, Berry D, Carlson D, Chirgadze N, et al.
J Med Chem
. 1996 Dec;
39(26):5137-58.
PMID: 8978843
As reported in our previous paper, a series of indole-3-acetamides which possessed potency and selectivity as inhibitors of human nonpancreatic secretory phospholipase A2(hnps-PLA2) was developed. The design of these compounds...
9.
Schevitz R, Bach N, Carlson D, Chirgadze N, CLAWSON D, DILLARD R, et al.
Nat Struct Biol
. 1995 Jun;
2(6):458-65.
PMID: 7664108
A lead compound obtained from a high volume human non-pancreatic secretory phospholipase A2 (hnps-PLA2) screen has been developed into a potent inhibitor using detailed structural knowledge of inhibitor binding to...
10.
Wery J, Schevitz R, CLAWSON D, Bobbitt J, Dow E, Gamboa G, et al.
Nature
. 1991 Jul;
352(6330):79-82.
PMID: 2062381
Phospholipases A2 (PLA2s) may be grouped into distinct families of proteins that catalyse the hydrolysis of the 2-acyl bond of phospholipids and perform a variety of biological functions. The best...