R W Lappe
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Explore the profile of R W Lappe including associated specialties, affiliations and a list of published articles.
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43
Citations
192
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Recent Articles
1.
Riley R, Sato H, Zhao Z, Thourani V, Jordan J, Fernandez A, et al.
J Thorac Cardiovasc Surg
. 2000 Aug;
120(2):350-8.
PMID: 10917953
Objectives: This study tested the hypothesis that a recombinant human C5a antagonist, CGS 32359, attenuates neutrophil activation and reduces infarct size in a porcine model of surgical revascularization. Methods: CGS...
2.
Chatelain R, Ghai R, Trapani A, Odorico L, Dardik B, De Lombaert S, et al.
J Pharmacol Exp Ther
. 1998 Mar;
284(3):974-82.
PMID: 9495857
Dual angiotensin-converting enzyme (ACE)/neutral endopeptidase (NEP) inhibitors, by decreasing angiotensin-II production and by preventing the degradation of atrial natriuretic peptide (ANP), may be useful for the treatment of hypertension and...
3.
Kwan A, Bavbek M, Jeng A, Maniara W, Toyoda T, Lappe R, et al.
J Neurosurg
. 1997 Aug;
87(2):281-6.
PMID: 9254094
Delayed cerebral ischemia due to cerebral vasospasm is a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (SAH). Increasing evidence implicates the potent vasoconstrictor peptide endothelin...
4.
Caner H, Kwan A, Arthur A, Jeng A, Lappe R, Kassell N, et al.
J Neurosurg
. 1996 Nov;
85(5):917-22.
PMID: 8893732
The potent vasoconstrictor peptide, endothelin-1 (ET-1), has been implicated in the pathophysiology of cerebral vasospasm that occurs after subarachnoid hemorrhage (SAH). This peptide is synthesized as a large prepropeptide that...
5.
In vitro and in vivo evaluation of an endothelin inhibitor reveals novel K+ channel opening activity
Webb R, Hu S, Sills M, Bazil M, Cioffi C, Shetty S, et al.
Biochem Biophys Res Commun
. 1996 Oct;
227(1):176-81.
PMID: 8858121
A low molecular weight endothelin (ET-1) inhibitor (Ex. 127, European Patent Application 404 525 A2, Takeda Chemical Ind., 1991), CGS 26061, was synthesized and evaluated to determine its mechanism of...
6.
Trapani A, De Lombaert S, Erion M, Ghai R, Peppard J, Lappe R, et al.
J Hypertens Suppl
. 1993 Dec;
11(5):S220-1.
PMID: 8158354
No abstract available.
7.
Trapani A, Balwierczak J, Lappe R, Stanton J, Graybill S, Hopkins M, et al.
Biochem Mol Biol Int
. 1993 Dec;
31(5):861-7.
PMID: 8136704
The IC50 values of phosphoramidon, CGS 25015, CGS 26129, thiorphan and benazeprilat for inhibition of endothelin converting enzyme partially purified from porcine aortic endothelial cells were 3.5, 18, 58, >...
8.
Rigel D, Olson R, Lappe R
Circ Res
. 1993 May;
72(5):1091-102.
PMID: 8477521
Recombinant desulfatohirudin (HI), a potent and specific thrombin inhibitor, was compared with heparin (HE) as an adjunct to streptokinase thrombolysis. In pentobarbital-anesthetized dogs, an occlusive thrombus (whole blood+thrombin) was introduced...
9.
Shetty S, Okada T, Webb R, Delgrande D, Lappe R
Biochem Biophys Res Commun
. 1993 Mar;
191(2):459-64.
PMID: 8461004
IRL 1620 (Suc-[Glu9,Ala11,15]-ET-1 (8-21)) (0.1 nM - 1 microM), a novel ETB-selective endothelin (ET) agonist, produced endothelium-dependent relaxations in precontracted rabbit mesenteric artery (2 nM, EC50) and endothelium-independent contractions in...
10.
Rigel D, Lappe R
J Cardiovasc Pharmacol
. 1993 Jan;
22 Suppl 8:S243-7.
PMID: 7509956
The effects of endothelin-1 (ET-1), an ET(A)/ETB-receptor agonist, and IRL 1620, a potent and selective ETB-receptor agonist, were assessed on left circumflex coronary artery diameter (sonomicrometry) and flow (electromagnetic flow...