R Tyler Mertens
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Explore the profile of R Tyler Mertens including associated specialties, affiliations and a list of published articles.
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12
Citations
60
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Recent Articles
1.
Orobator O, Mertens R, Obisesan O, Awuah S
J Biol Chem
. 2024 Oct;
300(12):107949.
PMID: 39481597
The elusiveness of triple-negative breast cancer from targeted therapy has redirected focus toward exploiting the metabolic shortcomings of these highly metastatic subtypes of breast cancer. Cueing from the metabolic heterogeneity...
2.
Mertens R, Kim J, Ofori S, Olelewe C, Kamitsuka P, Kwakye G, et al.
Biomed Pharmacother
. 2023 Dec;
170:116010.
PMID: 38128183
Triple-negative breast cancer (TNBC) is associated with metabolic heterogeneity and poor prognosis with limited treatment options. New treatment paradigms for TNBC remains an unmet need. Thus, therapeutics that target metabolism...
3.
Greif C, Mertens R, Berger G, Parkin S, Awuah S
RSC Chem Biol
. 2023 Aug;
4(8):592-599.
PMID: 37547458
Glioblastoma multiforme (GBM) is the most lethal brain cancer subtype, often advanced by the time of initial diagnosis. Existing treatment modalities including surgery, chemotherapy and radiation have been stymied by...
4.
Mertens R, Gukathasan S, Arojojoye A, Olelewe C, Awuah S
Chem Rev
. 2023 Apr;
123(10):6612-6667.
PMID: 37071737
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of inflammatory arthritis including rheumatoid and juvenile...
5.
Johnson A, Olelewe C, Kim J, Northcote-Smith J, Mertens R, Passeri G, et al.
Chem Sci
. 2023 Feb;
14(3):557-565.
PMID: 36741517
The anti-breast cancer stem cell (CSC) properties of a series of gold(i) complexes comprising various non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine 1-8 are reported. The most effective gold(i)-NSAID complex 1,...
6.
Mertens R, Greif C, Coogle J, Berger G, Parkin S, Watson M, et al.
J Catal
. 2022 Apr;
408:109-114.
PMID: 35368720
The development of oxidant-free gold-catalyzed cross coupling reactions involving aryl halides have been hamstrung by the lack of gold catalysts capable of performing oxidative addition at Au(I) centers. Herein, we...
7.
Mertens R, Jennings W, Ofori S, Kim J, Parkin S, Kwakye G, et al.
JACS Au
. 2021 Sep;
1(4):439-449.
PMID: 34467306
Mitochondrial structure and organization is integral to maintaining mitochondrial homeostasis and an emerging biological target in aging, inflammation, neurodegeneration, and cancer. The study of mitochondrial structure and its functional implications...
8.
Kim J, Ofori S, Mertens R, Parkin S, Awuah S
ChemMedChem
. 2021 Jun;
16(20):3222-3230.
PMID: 34159760
Chemical control of mitochondrial dynamics and bioenergetics can unravel fundamental biological mechanisms and therapeutics for several diseases including, diabetes and cancer. We synthesized stable, water-soluble gold(III) complexes (Auraformin) supported by...
9.
Synthesis, Characterization, and Antiproliferative Activity of Novel Chiral [QuinoxP*AuCl] Complexes
Arojojoye A, Mertens R, Ofori S, Parkin S, Awuah S
Molecules
. 2020 Dec;
25(23).
PMID: 33291802
Herein is reported the synthesis of two Au(III) complexes bearing the (,)-(-)-2,3-Bis(-butylmethylphosphino)quinoxaline (,-QuinoxP*) or (,)-(+)-2,3-Bis(-butylmethylphosphino)quinoxaline (-QuinoxP*) ligands. By reacting two stoichiometric equivalents of HAuCl.3HO to one equivalent of the corresponding...
10.
Mertens R, Parkin S, Awuah S
Acta Crystallogr E Crystallogr Commun
. 2019 Sep;
75(Pt 9):1311-1315.
PMID: 31523456
Imidazolium salts are common building blocks for functional materials and in the synthesis of N-heterocyclic carbene (NHC) as σ-donor ligands for stable metal complexes. The title salt, 1,3-bis-(4-hy-droxy-phen-yl)-1-imidazol-3-ium chloride (IOH·Cl),...