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R T Shiao

Explore the profile of R T Shiao including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 27
Followers 0
Related Specialties
Hematology
Oncology
Physiology
Top 10 Co-Authors
M N Gillespie
C E Freter
S Y Khera
A Wolfson
D Lavelle
J W Olson
Y H Chen
S Modi
S B McLeskey
H B Kostenbauder
Published In
Leuk Lymphoma
Am J Physiol
Blood
Am Rev Respir Dis
Affiliations
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Recent Articles
1.
Modulation of interleukin-6/interleukin-6 receptor cytokine loop in the treatment of multiple myeloma
Chen Y, Shiao R, Labayog J, Modi S, Lavelle D
Leuk Lymphoma . 1997 Dec; 27(1-2):11-23. PMID: 9373192
Interluekin-6 (IL-6)/IL-6 receptor (IL-6R) play a major role in autocrine/paracrine growth regulation of myeloma cells and are the central mediators for bone destruction and other systemic manifestations of multiple myeloma....
2.
Mechanisms of inhibition of IL-6-mediated immunoglobulin secretion by dexamethasone and suramin in human lymphoid and myeloma cell lines
Shiao R, McLeskey S, Khera S, Wolfson A, Freter C
Leuk Lymphoma . 1996 Apr; 21(3-4):293-303. PMID: 8726410
The cytokine IL-6 has been proposed as an autocrine growth factor in multiple myeloma, and is also required for stimulation of immunoglobulin production and secretion in normal plasma cells and...
3.
Inhibition of myeloma cell growth by dexamethasone and all-trans retinoic acid: synergy through modulation of interleukin-6 autocrine loop at multiple sites
Chen Y, Desai P, Shiao R, Lavelle D, Haleem A, Chen J
Blood . 1996 Jan; 87(1):314-23. PMID: 8547658
Interleukin-6 (IL-6)/IL-6 receptor (IL-6R) plays a major role in autocrine/paracrine growth regulation of myeloma cells. We investigated the effect of dexamethasone and all-trans retinoic acid, previously shown to modulate IL-6/IL-6R,...
4.
Dexamethasone and suramin inhibit cell proliferation and interleukin-6-mediated immunoglobulin secretion in human lymphoid and multiple myeloma cell lines
Shiao R, Miglietta L, Khera S, Wolfson A, Freter C
Leuk Lymphoma . 1995 May; 17(5-6):485-94. PMID: 7549842
Uncontrolled growth of neoplastic cells and unregulated production of immunoglobulin are major components of the morbidity and mortality of multiple myeloma. Suramin, a polysulfonated napthylurea, has antitumor activity in a...
5.
Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension
Shiao R, Kostenbauder H, Olson J, Gillespie M
Am J Physiol . 1990 Dec; 259(6 Pt 1):L351-8. PMID: 2148056
Chronic hypoxia causes polyamine-dependent hypertensive pulmonary vascular remodeling (J. E. Atkinson. J. W. Olson, R. J. Altierre, and M. N. Gillespie, J. Appl. Physiol. 62: 1562-1568, 1987), but mechanisms by...
6.
Polyamines and epidermal growth factor in monocrotaline-induced pulmonary hypertension
Gillespie M, Rippetoe P, Haven C, Shiao R, Orlinska U, Maley B, et al.
Am Rev Respir Dis . 1989 Nov; 140(5):1463-6. PMID: 2510568
Multiple lines of evidence suggest that the polyamines, a family of low-molecular-weight organic cations with documented regulatory note in cell growth and differentiation, are involved with hyperplastic and hypertrophic responses...