R Spanagel
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Explore the profile of R Spanagel including associated specialties, affiliations and a list of published articles.
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84
Citations
3037
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Recent Articles
1.
Broccoli L, Uhrig S, von Jonquieres G, Schonig K, Bartsch D, Justice N, et al.
Psychopharmacology (Berl)
. 2018 Apr;
235(6):1821-1833.
PMID: 29700576
Rationale: The corticotropin-releasing hormone (CRH) system is a key mediator of stress-induced responses in alcohol-seeking behavior. Recent research has identified the central nucleus of the amygdala (CeA), a brain region...
2.
Bernardi R, Zohsel K, Hirth N, Treutlein J, Heilig M, Laucht M, et al.
Transl Psychiatry
. 2016 Jul;
6(7):e861.
PMID: 27459726
It has been proposed that vulnerability to nicotine addiction is moderated by variation at the μ-opioid receptor locus (OPRM1), but results from human studies vary and prospective studies based on...
3.
Hadar R, Vengeliene V, Barroeta Hlusicke E, Canals S, Noori H, Wieske F, et al.
Transl Psychiatry
. 2016 Jun;
6(6):e840.
PMID: 27327255
Case reports indicate that deep-brain stimulation in the nucleus accumbens may be beneficial to alcohol-dependent patients. The lack of clinical trials and our limited knowledge of deep-brain stimulation call for...
4.
Sellmann C, Villarin Pildain L, Schmitt A, Leonardi-Essmann F, Durrenberger P, Spanagel R, et al.
Eur Arch Psychiatry Clin Neurosci
. 2013 Nov;
264(4):297-309.
PMID: 24287731
We investigated gene expression pattern obtained from microarray data of 10 schizophrenia patients and 10 control subjects. Brain tissue samples were obtained postmortem; thus, the different ages of the patients...
5.
Karrenbauer B, Muller C, Ho Y, Spanagel R, Huston J, Schwarting R, et al.
J Neuroimmunol
. 2011 Jul;
237(1-2):23-32.
PMID: 21726905
We investigated the impact of systemically injected IL-2 (2.5 μg/kg, i.p.) on serotonergic and dopaminergic neurotransmission in various cortical areas by in-vivo microdialysis. IL-2 lastingly reduced extracellular 5-HT levels in...
6.
Schneider S, Peters J, Bromberg U, Brassen S, Menz M, Miedl S, et al.
Neuroimage
. 2011 Feb;
56(3):1847-53.
PMID: 21316467
Previous studies have observed a sex-dependent lateralization of amygdala activation related to emotional memory. Specifically, it was shown that the activity of the right amygdala correlates significantly stronger with memory...
7.
Schumann G, Loth E, Banaschewski T, Barbot A, Barker G, Buchel C, et al.
Mol Psychiatry
. 2010 Nov;
15(12):1128-39.
PMID: 21102431
A fundamental function of the brain is to evaluate the emotional and motivational significance of stimuli and to adapt behaviour accordingly. The IMAGEN study is the first multicentre genetic-neuroimaging study...
8.
Sommer J, Schmitt A, Heck M, Schaeffer E, Fendt M, Zink M, et al.
Eur Arch Psychiatry Clin Neurosci
. 2010 Oct;
260 Suppl 2:S81-9.
PMID: 20945070
Obstetric complications play a role in the pathophysiology of schizophrenia. However, the biological consequences during neurodevelopment until adulthood are unknown. Microarrays have been used for expression profiling in four brain...
9.
Kiefer F, Witt S, Frank J, Richter A, Treutlein J, Lemenager T, et al.
Pharmacogenomics J
. 2010 Jun;
11(5):368-74.
PMID: 20585342
In alcoholism, both relapse to alcohol drinking and treatment response are suggested to be genetically modulated. This study set out to determine whether the top 15 single nucleotide polymorphisms (SNPs)...
10.
Matthaus F, Smith V, Fogtman A, Sommer W, Leonardi-Essmann F, Lourdusamy A, et al.
Pharmacopsychiatry
. 2009 May;
42 Suppl 1:S118-28.
PMID: 19434550
Lists of differentially expressed genes in a disease have become increasingly more comprehensive with improvements on all technical levels. Despite statistical cutoffs of 99% or 95% confidence intervals, the number...