F Holsboer
Overview
Explore the profile of F Holsboer including associated specialties, affiliations and a list of published articles.
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475
Citations
11121
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Recent Articles
1.
Yu S, Zutshi I, Stoffel R, Zhang J, Ventura-Silva A, Sousa N, et al.
Transl Psychiatry
. 2017 Jan;
7(1):e990.
PMID: 28045461
The dynamic turnover of hippocampal neurons is implicated in the regulation of cognitive and affective behavior. Extending our previous demonstration that administration of dexamethasone (ND) to neonatal rats depletes the...
2.
Breitfeld J, Scholl C, Steffens M, Brandenburg K, Probst-Schendzielorz K, Efimkina O, et al.
Transl Psychiatry
. 2016 Nov;
6(11):e950.
PMID: 27845776
The current therapy success of depressive disorders remains in need of improvement due to low response rates and a delay in symptomatic improvement. Reliable functional biomarkers would be necessary to...
3.
Antunica-Noguerol M, Budzinski M, Druker J, Gassen N, Sokn M, Senin S, et al.
Cell Death Differ
. 2016 May;
23(10):1579-91.
PMID: 27177020
FK506-binding protein 51 (FKBP51) regulates the activity of the glucocorticoid receptor (GR), and is therefore a key mediator of the biological actions of glucocorticoids. However, the understanding of the molecular...
4.
Santarelli S, Wagner K, Labermaier C, Uribe A, Dournes C, Balsevich G, et al.
Stress
. 2015 Nov;
19(1):83-90.
PMID: 26585320
Major depression is a multifactorial disease, involving both environmental and genetic risk factors. Recently, SLC6A15 - a neutral amino acid transporter mainly expressed in neurons - was proposed as a...
5.
Parrish Waters R, Rivalan M, Bangasser D, Deussing J, Ising M, Wood S, et al.
Neurosci Biobehav Rev
. 2015 Aug;
58:63-78.
PMID: 26271720
Major depressive disorder (MDD) is a devastating disease affecting over 300 million people worldwide, and costing an estimated 380 billion Euros in lost productivity and health care in the European...
6.
Adamczyk M, Ambrosius U, Lietzenmaier S, Wichniak A, Holsboer F, Friess E
Transl Psychiatry
. 2015 Jul;
5:e598.
PMID: 26151926
The trait-like nature of electroencephalogram (EEG) is well established. Furthermore, EEG of wake and non-rapid eye movement (non-REM) sleep has been shown to be highly heritable. However, the genetic effects...
7.
Gassen N, Hartmann J, Zannas A, Kretzschmar A, Zschocke J, Maccarrone G, et al.
Mol Psychiatry
. 2015 Apr;
21(2):277-89.
PMID: 25849320
Psychotropic medications target glycogen synthase kinase 3β (GSK3β), but the functional integration with other factors relevant for drug efficacy is poorly understood. We discovered that the suggested psychiatric risk factor...
8.
Hennings J, Uhr M, Klengel T, Weber P, Putz B, Touma C, et al.
Transl Psychiatry
. 2015 Apr;
5:e538.
PMID: 25826113
Response to antidepressant treatment is highly variable with some patients responding within a few weeks, whereas others have to wait for months until the onset of clinical effects. Gene expression...
9.
Gerez J, Tedesco L, Bonfiglio J, Fuertes M, Barontini M, Silberstein S, et al.
Oncogene
. 2014 Dec;
34(37):4855-66.
PMID: 25500545
Somatic mutations or loss of von Hippel-Lindau (pVHL) happen in the majority of VHL disease tumors, which present a constitutively active Hypoxia Inducible Factor (HIF), essential for tumor growth. Recently...
10.
Sotnikov S, Markt P, Malik V, Chekmareva N, Naik R, Sah A, et al.
Transl Psychiatry
. 2014 Feb;
4:e359.
PMID: 24518397
The continuum of physiological anxiety up to psychopathology is not merely dependent on genes, but is orchestrated by the interplay of genetic predisposition, gene x environment and epigenetic interactions. Accordingly,...