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R Schulte-Hermann

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Articles 135
Citations 1751
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Recent Articles
1.
Schuppler J, Schulte-Hermann R, Timmermann-Trosiener I, Gunzel P
Toxicol Pathol . 2017 Jan; 10(2):132-143. PMID: 28094732
In standard two year tumorigenicity studies some gestagens, alone or in combination with an estrogen have been shown to produce proliferative liver lesions (PLL) in rats. Estrogens in general have...
2.
Schulte-Hermann R, Timmermann-Trosiener I, Schuppler J
Toxicol Pathol . 2017 Jan; 10(2):63-68. PMID: 28094714
Putative preneoplastic foci (islands) of altered hepatocytes were induced by single doses of initiating hepatocarcinogens and identified by various histochemical and morphological markers. DNA synthesis, measured by H-thymidine and autoradiography,...
3.
Frost K, Seir K, Lackner A, Grusch M, Grasl-Kraupp B, Schulte-Hermann R, et al.
Br J Cancer . 2011 Mar; 104(8):1303-12. PMID: 21407220
Background: Activins and inhibins belong to the TGFβ-superfamily, which controls cell proliferation and differentiation in many organs. Activin A, the dimer of inhibin βA subunit, acts strongly anti-proliferative in hepatocytes....
4.
Bursch W, Ellinger A, Torok L, Parzefall W, Coulibaly S, Hochegger K, et al.
Toxicol In Vitro . 2010 Jul; 11(5):579-88. PMID: 20654355
Active cell death (ACD) comprises several subtypes as indicated by morphology at light- and electron-microscopical level: for example type I ACD or apoptosis, with nuclear condensation, fragmentation, cytoplasmic condensation; type...
5.
Parzefall W, Erber E, Kainzbauer E, Schulte-Hermann R
Toxicol In Vitro . 2010 Jul; 10(2):183-93. PMID: 20650196
Enhanced cell proliferation may favour DNA-damaging processes (tumour initiation) as well as the expansion of clones of altered cells (tumour promotion). The latter process appears to be responsible for carcinogenesis...
6.
Sagmeister S, Eisenbauer M, Pirker C, Mohr T, Holzmann K, Zwickl H, et al.
Br J Cancer . 2008 Jul; 99(1):151-9. PMID: 18594539
To enable detailed analyses of cell interactions in tumour development, new epithelial and mesenchymal cell lines were established from human hepatocellular carcinoma by spontaneous outgrowth in culture. We obtained several...
7.
Bichler J, Cavin C, Simic T, Chakraborty A, Ferk F, Hoelzl C, et al.
Food Chem Toxicol . 2007 Mar; 45(8):1428-36. PMID: 17376579
Aim of the study was to investigate the impact of coffee on DNA-stability in humans. DNA-damage was monitored in lymphocytes of eight individuals with single cell gel electrophoresis assays before...
8.
Schausberger E, Hufnagl K, Parzefall W, Gerner C, Kandioler-Eckersberger D, Wrba F, et al.
Br J Cancer . 2004 Nov; 91(11):1955-63. PMID: 15534611
The pro-peptide of transforming growth factor alpha (proTGFalpha) was recently found in hepatocyte nuclei preparing for DNA replication, which suggests a role of nuclear proTGFalpha for mitogenic signalling. This study...
9.
Bursch W, Grasl-Kraupp B, Wastl U, Hufnagl K, Chabicovsky M, Taper H, et al.
Toxicol Lett . 2004 Apr; 149(1-3):25-35. PMID: 15093245
Apoptosis constitutes one of the organisms defense lines against cancer. We investigated whether failure of apoptosis may be concurrently causative for the high cancer susceptibility in C3H/He as compared to...
10.
Wheeler M, Smutney O, Check J, Rusyn I, Schulte-Hermann R, Thurman R
Am J Physiol Gastrointest Liver Physiol . 2002 Oct; 284(2):G302-12. PMID: 12388208
Liver regeneration after partial hepatectomy (PH) involves several signaling mechanisms including activation of the small GTPases Ras and RhoA in response to mitogens leading to DNA synthesis and cell proliferation....