R Savva
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Explore the profile of R Savva including associated specialties, affiliations and a list of published articles.
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12
Citations
310
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Recent Articles
1.
Rosler A, Panayotou G, Hornby D, Barlow T, Brown T, Pearl L, et al.
Nucleosides Nucleotides Nucleic Acids
. 2001 Feb;
19(10-12):1505-16.
PMID: 11200255
2',4'-Dideoxy-4'-methyleneuridine incorporated into oligodeoxynucleotides forms regular B-DNA duplexes as shown by Tm and CD measurements. Such oligomers are not cleaved by the DNA repair enzyme, UDG, which cleaves the glycosylic...
2.
Barrett T, Scharer O, Savva R, Brown T, Jiricny J, Verdine G, et al.
EMBO J
. 1999 Dec;
18(23):6599-609.
PMID: 10581234
The bacterial mismatch-specific uracil-DNA glycosylase (MUG) and eukaryotic thymine-DNA glycosylase (TDG) enzymes form a homologous family of DNA glycosylases that initiate base-excision repair of G:U/T mismatches. Despite low sequence homology,...
3.
Barrett T, Savva R, Barlow T, Brown T, Jiricny J, Pearl L
Nat Struct Biol
. 1998 Aug;
5(8):697-701.
PMID: 9699633
Base-excision of a self-complementary oligonucleotide with central G:T mismatches by the G:T/U-specific mismatch DNA glycosylase (MUG), generates an unusual DNA structure which is remarkably similar in conformation to an interstrand...
4.
Barrett T, Savva R, Panayotou G, Barlow T, Brown T, Jiricny J, et al.
Cell
. 1998 Mar;
92(1):117-29.
PMID: 9489705
G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises...
5.
Panayotou G, Brown T, Barlow T, Pearl L, Savva R
J Biol Chem
. 1998 Feb;
273(1):45-50.
PMID: 9417045
Site-directed mutants of the herpes simplex virus type 1 uracil-DNA glycosylase lacking catalytic activity have been used to probe the substrate recognition of this highly conserved and ubiquitous class of...
6.
Koulis A, Cowan D, Pearl L, Savva R
FEMS Microbiol Lett
. 1996 Oct;
143(2-3):267-71.
PMID: 8837481
Hyperthermophiles exist in conditions which present an increased threat to the informational integrity of their DNA, particularly by hydrolytic damage. As in mesophilic organisms, specific activities must exist to restore...
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Savva R, Pearl L
Nat Struct Biol
. 1995 Sep;
2(9):752-7.
PMID: 7552746
The Bacillus subtilis bacteriophages PBS-1 and PBS-2 protect their uracil-containing DNA by expressing an inhibitor protein (UGI) which inactivates the host uracil-DNA glycosylase (UDGase) base-excision repair enzyme. Also, PBS1/2 UGI...
10.
Savva R, Pearl L
Proteins
. 1995 Jul;
22(3):287-9.
PMID: 7479702
The uracil-DNA glycosylase inhibitory protein (UGI) from the bacteriophage PBS-1 has been cloned and overexpressed. The nucleotide sequence is identical to that for the previously described PBS-2 inhibitor. The recombinant...