R S Addison
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Explore the profile of R S Addison including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
134
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Recent Articles
11.
Addison R, Duffy S, Mathers S
J Chromatogr Sci
. 1999 Mar;
37(3):61-4.
PMID: 10089595
A simple high-performance liquid chromatography assay using fluorescence detection for the major metabolite of the gastric prokinetic drug cisapride, norcisapride, is presented. Analysis is performed using an Alltech Platinum EPS...
12.
Addison R, Franklin M, Hooper W
J Chromatogr B Biomed Sci Appl
. 1998 Nov;
716(1-2):153-60.
PMID: 9824228
A sensitive, robust gas chromatographic-mass spectrometric assay suitable for use in pharmacokinetic or bioequivalence studies is presented for the selective serotonin reuptake inhibitor, fluoxetine, and its major metabolite, norfluoxetine (N-desmethylfluoxetine)....
13.
Franklin M, Addison R, Baker P, Hooper W
J Chromatogr B Biomed Sci Appl
. 1998 Mar;
705(1):47-54.
PMID: 9498669
An enhanced, sensitive GC-MS assay is presented for the highly specific angiotensin-converting enzyme (ACE) inhibitor, captopril. This method improves previously published assays by using solid NEM as stabilizer in the...
14.
Rasiah R, Addison R, Roberts M, Mortimer R
J Pharmacol Toxicol Methods
. 1997 Oct;
38(1):19-25.
PMID: 9339412
We describe a method for multiple indicator dilution studies in the isolated perfused human placental lobule developed to investigate the relationships between changes in pressure and flow and solute clearance....
15.
Mortimer R, Cannell G, Addison R, Johnson L, Roberts M, Bernus I
J Clin Endocrinol Metab
. 1997 Sep;
82(9):3099-102.
PMID: 9284751
Propylthiouracil (PTU) is widely believed to cross the placenta less freely than methimazole (MMI) and is therefore regarded as the preferred drug for treatment of hyperthyroidism in pregnancy. Clinical studies...
16.
Mortimer R, Galligan J, Cannell G, Addison R, Roberts M
J Clin Endocrinol Metab
. 1996 Jun;
81(6):2247-9.
PMID: 8964859
Placental deiodination of T4 to rT3 has been proposed as the factor controlling materno-fetal transmission of T4. We investigated T4 transfer in the isolated perfused human placental lobule with and...
17.
Wu Z, Thompson M, Roberts M, Addison R, Cannell G, Grabs A, et al.
J Chromatogr B Biomed Appl
. 1995 Nov;
673(2):267-79.
PMID: 8611961
A sensitive, specific and rapid reversed-phase high-performance liquid chromatographic (HPLC) assay was developed for the quantitation of melphalan and its hydrolysis products in samples from the isolated perfusion of human...
18.
Clark J, Grabs A, Parsons P, Smithers B, Addison R, Roberts M
Melanoma Res
. 1994 Dec;
4(6):365-70.
PMID: 7703715
Isolated limb perfusion with melphalan is a long-standing treatment for melanoma but the clinical conditions have not been subjected to a systematic evaluation. In order to establish optimal conditions for...
19.
Maguire D, Cannell G, Addison R
Adv Exp Med Biol
. 1994 Jan;
345:709-15.
PMID: 8079777
No abstract available.
20.
Addison R, Maguire D, Mortimer R, Roberts M, Cannell G
J Steroid Biochem Mol Biol
. 1993 Mar;
44(3):315-20.
PMID: 8461264
Prednisolone is metabolized in the perfused human placental lobule to prednisone, 20 alpha-dihydroprednisone, 20 beta-dihydroprednisone and 20 beta-dihydroprednisolone. The pathway of metabolite formation was defined in perfusions of placental lobules...