R Regazzi
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Explore the profile of R Regazzi including associated specialties, affiliations and a list of published articles.
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56
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1477
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Recent Articles
1.
Roat R, Hossain M, Christopherson J, Free C, Jain S, Guay C, et al.
Am J Transplant
. 2016 Oct;
17(4):992-1007.
PMID: 27700000
Currently there is no effective approach for monitoring early β-cell loss during islet graft rejection following human islet transplantation (HIT). Due to ethical and technical constraints, it is difficult to...
2.
Motterle A, Sanchez-Parra C, Regazzi R
Diabetes Obes Metab
. 2016 Sep;
18 Suppl 1:41-50.
PMID: 27615130
Pancreatic β-cells are highly specialized cells committed to secrete insulin in response to changes in the level of nutrients, hormones and neurotransmitters. Chronic exposure to elevated concentrations of glucose, fatty...
3.
Guay C, Regazzi R
Diabetes Metab
. 2015 Apr;
41(5):369-77.
PMID: 25910875
Insulin secretion from pancreatic β cells plays a central role in the control of blood glucose levels. The amount of insulin released by β cells is precisely adjusted to match...
4.
Guay C, Jacovetti C, Nesca V, Motterle A, Tugay K, Regazzi R
Diabetes Obes Metab
. 2012 Aug;
14 Suppl 3:12-21.
PMID: 22928560
Pancreatic β-cells play a central role in glucose homeostasis by tightly regulating insulin release according to the organism's demand. Impairment of β-cell function due to hostile environment, such as hyperglycaemia...
5.
Roggli E, Gattesco S, Pautz A, Regazzi R
Diabetologia
. 2011 Dec;
55(6):1699-708.
PMID: 22159912
Aims/hypothesis: Chronic exposure of pancreatic beta cells to proinflammatory cytokines leads to impaired insulin secretion and apoptosis. ARE/poly(U)-binding factor 1 (AUF1) belongs to a protein family that controls mRNA stability...
6.
Favre D, Niederhauser G, Fahmi D, Plaisance V, Brajkovic S, Beeler N, et al.
Diabetologia
. 2011 May;
54(9):2337-46.
PMID: 21547497
Aims/hypothesis: Pro-atherogenic and pro-oxidant, oxidised LDL trigger adverse effects on pancreatic beta cells, possibly contributing to diabetes progression. Because oxidised LDL diminish the expression of genes regulated by the inducible...
7.
Kolfschoten I, Roggli E, Nesca V, Regazzi R
Diabetes Obes Metab
. 2009 Oct;
11 Suppl 4:118-29.
PMID: 19817794
The discovery in mammalian cells of hundreds of small RNA molecules, called microRNAs, with the potential to modulate the expression of the majority of the protein-coding genes has revolutionized many...
8.
Martin D, Allagnat F, Chaffard G, Caille D, Fukuda M, Regazzi R, et al.
Diabetologia
. 2008 Apr;
51(8):1429-39.
PMID: 18385973
Aims/hypothesis: The expression of several neuronal genes in pancreatic beta cells is due to the absence of the transcription factor repressor element 1 (RE-1) silencing transcription factor (REST). The identification...
9.
Abderrahmani A, Niederhauser G, Favre D, Abdelli S, Ferdaoussi M, Yang J, et al.
Diabetologia
. 2007 Apr;
50(6):1304-14.
PMID: 17437081
Aims/hypothesis: We explored the potential adverse effects of pro-atherogenic oxidised LDL-cholesterol particles on beta cell function. Materials And Methods: Isolated human and rat islets and different insulin-secreting cell lines were...
10.
Abderrahmani A, Plaisance V, Lovis P, Regazzi R
Biochem Soc Trans
. 2006 Oct;
34(Pt 5):696-700.
PMID: 17052177
The last decade has witnessed spectacular progress in the identification of the protein apparatus required for exocytosis of neurotransmitters, peptide hormones and other bioactive products. In striking contrast, our knowledge...