R R Freimuth
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Explore the profile of R R Freimuth including associated specialties, affiliations and a list of published articles.
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11
Citations
412
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Recent Articles
1.
Freimuth R, Formea C, Hoffman J, Matey E, Peterson J, Boyce R
CPT Pharmacometrics Syst Pharmacol
. 2017 Jan;
6(3):153-155.
PMID: 28109071
The explosive growth of patient-specific genomic information relevant to drug therapy will continue to be a defining characteristic of biomedical research. To implement drug-based personalized medicine (PM) for patients, clinicians...
2.
Luzum J, Pakyz R, Elsey A, Haidar C, Peterson J, Whirl-Carrillo M, et al.
Clin Pharmacol Ther
. 2017 Jan;
102(3):502-510.
PMID: 28090649
Numerous pharmacogenetic clinical guidelines and recommendations have been published, but barriers have hindered the clinical implementation of pharmacogenetics. The Translational Pharmacogenetics Program (TPP) of the National Institutes of Health (NIH)...
3.
Kalman L, Agundez J, Appell M, Black J, Bell G, Boukouvala S, et al.
Clin Pharmacol Ther
. 2015 Oct;
99(2):172-85.
PMID: 26479518
This article provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting. Presently, sequence variants identified by PGx tests are described using...
4.
Martin M, Hoffman J, Freimuth R, Klein T, Dong B, Pirmohamed M, et al.
Clin Pharmacol Ther
. 2014 Feb;
95(5):499-500.
PMID: 24561393
The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for HLA-B Genotype and Abacavir Dosing were originally published in April 2012. We reviewed recent literature and concluded that none of the evidence...
5.
Shuldiner A, Relling M, Peterson J, Hicks J, Freimuth R, Sadee W, et al.
Clin Pharmacol Ther
. 2013 Apr;
94(2):207-10.
PMID: 23588301
No abstract available.
6.
King C, Yu J, Freimuth R, McLeod H, Marsh S
Pharmacogenomics J
. 2004 Nov;
5(1):54-9.
PMID: 15534626
Excision Repair Cross-Complementing Rodent Repair Group 2 (ERCC2) plays an important role in DNA repair by eliminating bulky DNA adducts produced by platinum agents during the nucleotide excision repair pathway....
7.
Freimuth R, Wiepert M, Chute C, Wieben E, Weinshilboum R
Pharmacogenomics J
. 2003 Dec;
4(1):54-65.
PMID: 14676822
A total of 10 SULT genes are presently known to be expressed in human tissues. We performed a comprehensive genome-wide search for novel SULT genes using two different but complementary...
8.
Thomae B, Eckloff B, Freimuth R, Wieben E, Weinshilboum R
Pharmacogenomics J
. 2002 May;
2(1):48-56.
PMID: 11990382
SULT2A1 catalyzes the sulfate conjugation of dehydroepiandrosterone (DHEA) as well as other steroids. As a step toward pharmacogenetic studies, we have 'resequenced' SULT2A1 using 60 DNA samples from African-American and...
9.
Freimuth R, Eckloff B, Wieben E, Weinshilboum R
Pharmacogenetics
. 2001 Dec;
11(9):747-56.
PMID: 11740338
Sulfotransferase (SULT) enzymes catalyze an important phase II reaction in the biotransformation of many drugs and other xenobiotics. We previously cloned the human SULT1C1 cDNA and gene as steps toward...
10.
Freimuth R, Raftogianis R, Wood T, Moon E, Kim U, Xu J, et al.
Genomics
. 2000 Apr;
65(2):157-65.
PMID: 10783263
Sulfate conjugation catalyzed by sulfotransferase (SULT) enzymes is an important pathway in the biotransformation of many drugs, other xenobiotics, neurotransmitters, and hormones. We previously described a human cDNA, SULT1C1, that...