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R O Epemolu

Explore the profile of R O Epemolu including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 32
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Recent Articles
1.
Choudhury R, Epemolu R, Rai B, Hider R, Singh S
Drug Metab Dispos . 1997 Mar; 25(3):332-9. PMID: 9172951
Metabolism and pharmacokinetics of 1-(2'-trimethylacetoxyethyl]-2-ethyl-3-hydroxypyridin-4-one (CP117) were studied in the rat. Urinary recovery studies were conducted in normal (oral and intravenous) and iron-overloaded rats (500 mg Fe/kg body weight; oral...
2.
An Z, Wang X, Willmott N, Chander S, Tickle S, Docherty A, et al.
Clin Exp Metastasis . 1997 Mar; 15(2):184-95. PMID: 9062395
In this study, we describe the activity of CT1746, an orally-active synthetic MMP inhibitor that has a greater specificity for gelatinase A, gelatinase B and stromelysin than for interstitial collagenase...
3.
Singh S, Choudhury R, Epemolu R, Hider R
Eur J Drug Metab Pharmacokinet . 1996 Jan; 21(1):33-41. PMID: 8839676
The urinary recovery (p.o.) and pharmacokinetics (i.v. and p.o.) of two compounds from the 1-hydroxyalkyl-3-hydroxypyridin-4-one series. 1-(2'-hydroxyethyl)-2-ethyl-3-hydroxypyridine-4-one (CP102) and 1-(3'-hydroxypropyl)-2-ethyl-3-hydroxypyridin-4-one (CP106) were studied in the rat. The pharmacokinetics of the...
4.
Epemolu R, Ackerman R, Porter J, Hider R, Damani L, Singh S
J Pharm Biomed Anal . 1994 Jul; 12(7):923-30. PMID: 7981322
Sensitive and selective high performance liquid chromatographic (HPLC) methods for the quantification of 1,2-diethyl-3-hydroxypyridin-4-one (CP94), its iron complex [Fe(III) (CP94)3] and glucuronide metabolite (CP94-GLUC) in urine and serum of thalassaemic...
5.
Singh S, Epemolu R, Dobbin P, Tilbrook G, Ellis B, Damani L, et al.
Drug Metab Dispos . 1992 Mar; 20(2):256-61. PMID: 1352218
The urinary metabolic profiles of two novel orally active iron chelators, 1,2-dimethyl-3-hydroxypyridin-4-one (CP20 or L1) and 1,2-diethyl-3-hydroxypyridin-4-one (CP94), have been studied in rats. The metabolism of CP20 was also studied...
6.
Epemolu R, Singh S, Hider R, Damani L
J Chromatogr . 1992 Jan; 573(1):178-82. PMID: 1564101
A sensitive and selective high-performance liquid chromatographic (HPLC) method for the analysis of 1,2-diethyl-3-hydroxypyridin-4-one (CP94, I) and its 2-(1-hydroxyethyl) metabolite (II) in rat blood is described. I, II and the...