R N Harkins
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Explore the profile of R N Harkins including associated specialties, affiliations and a list of published articles.
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41
Citations
1592
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Recent Articles
1.
Petry H, Brooks A, Orme A, Wang P, Liu P, Xie J, et al.
Gene Ther
. 2007 Oct;
15(1):54-60.
PMID: 17960164
Neutralizing antibodies (nAB) at the time of administration hamper the effectiveness of adeno-associated virus (AAV) as a clinical DNA delivery system. The present study was designed to investigate if AAV...
2.
Harkins R, Szymanski P, Petry H, Brooks A, Qian H, Schaefer C, et al.
Gene Ther
. 2007 Jul;
15(1):1-11.
PMID: 17637794
A single plasmid regulated expression vector based upon a mifepristone-inducible two plasmid system, termed pBRES, has been constructed and tested in mice using murine interferon-b (mIFNb) as the transgene. The...
3.
Harris A, Adler M, Brink J, Lin R, Foehr M, Ferrer M, et al.
Biochem Biophys Res Commun
. 1998 Oct;
251(1):220-4.
PMID: 9790934
The EGF domain of heregulin has all the receptor binding characteristics of full-length heregulin and has strong homology to the ligands for erbB-1. Despite this, it does not bind erbB-1...
4.
McInnes C, Hoyt D, Harkins R, Pagila R, Debanne M, OConnor-McCourt M, et al.
J Biol Chem
. 1996 Dec;
271(50):32204-11.
PMID: 8943277
The study of human transforming growth factor-alpha (TGF-alpha) in complex with the epidermal growth factor (EGF) receptor extracellular domain has been undertaken in order to generate information on the interactions...
5.
Pu H, Betts M, Harkins R, Perez H, Croze E
J Biol Chem
. 1995 Nov;
270(44):26033-6.
PMID: 7592797
The type I interferon (IFN) receptor complex is assumed to be composed of multiple protein subunits. Recently, two proteins have been identified as potential receptor components, both of which share...
6.
Chan S, Antoniucci D, Fok K, Alajoki M, Harkins R, Thompson S, et al.
J Biol Chem
. 1995 Sep;
270(38):22608-13.
PMID: 7673253
HER2, the erbB-2/neu proto-oncogene product, is a 185-kDa transmembrane glycoprotein related to the epidermal growth factor receptor. Overexpression of HER2 was reported in several human adenocarcinomas, including mammary and ovarian...
7.
Seto M, Harkins R, Adler M, Whitlow M, Church W, Croze E
Protein Sci
. 1995 Apr;
4(4):655-70.
PMID: 7613464
Human interferon-alpha 8 (HuIFN alpha 8), a type I interferon (IFN), is a cytokine belonging to the hematopoietic super-family that includes human growth hormone (HGH). Recent data identified two human...
8.
Hoyt D, Harkins R, Debanne M, OConnor-McCourt M, Sykes B
Biochemistry
. 1994 Dec;
33(51):15283-92.
PMID: 7803391
The interaction of transforming growth factor alpha (TGF-alpha) with the complete extracellular domain of the epidermal growth factor receptor (EGFR-ED) was examined by nuclear magnetic resonance (NMR) spectroscopy. The 1H...
9.
Differential expression of two genes for 1-aminocyclopropane-1-carboxylate synthase in tomato fruits
Olson D, White J, Edelman L, Harkins R, Kende H
Proc Natl Acad Sci U S A
. 1991 Jun;
88(12):5340-4.
PMID: 1711229
1-Aminocyclopropane-1-carboxylate synthase (ACC synthase; S-adenosyl-L-methionine methylthioadenosine-lyase, EC 4.4.1.14) is the regulated enzyme in the biosynthetic pathway of the plant hormone ethylene. A full-length cDNA encoding this enzyme has been cloned...
10.
Jhappan C, Stahle C, Harkins R, Fausto N, Smith G, Merlino G
Cell
. 1990 Jun;
61(6):1137-46.
PMID: 2350785
To define the role of TGF alpha in normal tissue function and in pathogenesis, transgenic mice have been generated bearing a fusion gene consisting of the mouse metallothionein 1 promoter...