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R Marcus Fancher

Explore the profile of R Marcus Fancher including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 43
Followers 0
Related Specialties
Pharmacology
Chemistry
Pharmacy
Top 10 Co-Authors
Hong Shen
Michael Sinz
Xue-Qing Chen
Yurong Lai
Punit Marathe
Ramaswamy Iyer
Yang Hong
Gabe Mintier
Cliff Chen
A David Rodrigues
Published In
Drug Metab Dispos
J Pharmacol Exp Ther
J Pharm Sci
Int J Toxicol
Int J Pharm
Affiliations
Soon will be listed here.
Recent Articles
1.
Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions
Chu J, Panfen E, Wang L, Marino A, Chen X, Fancher R, et al.
Pharm Res . 2023 Jul; 40(11):2567-2584. PMID: 37523014
Purpose: The differences between intestinal and systemic (hepatic and renal) P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) roles in drug disposition are difficult to define. Accordingly, we characterized Encequidar...
2.
Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein-Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo
Zhang Y, Shipkova P, Warrack B, Nelson D, Wang L, Huo R, et al.
Drug Metab Dispos . 2023 Apr; 51(7):851-861. PMID: 37055191
Advancement of endogenous biomarkers for drug transporters as a tool for assessing drug-drug interactions (DDIs) depends on initial identification of biomarker candidates and relies heavily on biomarker validation and its...
3.
Increasing the Reuse of Protein Non-Naïve Nonhuman Primates in Pharmaceutical Drug Discovery and Development: An Overview and Industry Position on the Challenges and Benefits
Mattis C, Bratcher N, Burns M, Carosino C, de Zafra C, Fancher R, et al.
Int J Toxicol . 2022 Jun; 41(4):291-296. PMID: 35656559
The IQ Consortium NHP Reuse Working Group (WG) comprises members from 15 pharmaceutical and biotechnology companies. In 2020, the WG developed and distributed a detailed questionnaire on protein non-naïve NHP...
4.
Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression
Zhang Y, Chen C, Chen S, Chen X, Shuster D, Puszczalo P, et al.
J Pharmacol Exp Ther . 2020 Jul; 375(1):139-151. PMID: 32719071
Organic anion-transporting polypeptide (OATP) 1B induction is an evolving mechanism of drug disposition and interaction. However, there are contradictory reports describing OATP1B expression in hepatocytes and liver biopsies after administration...
5.
Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition
Gu X, Wang L, Gan J, Fancher R, Tian Y, Hong Y, et al.
Drug Metab Dispos . 2020 Jun; 48(8):724-734. PMID: 32482623
Despite a recent expansion in the recognition of the potential utility of coproporphyrin (CP) as an endogenous biomarker of organic anion-transporting polypeptide (OATP) 1B activity, there have been few detailed...
6.
A convenient strategy to overcome interference in LC-MS/MS analysis: Application in a microdose absolute bioavailability study
Yuan L, Huang C, Liu-Kreyche P, Voronin K, Fancher R, Allentoff A, et al.
J Pharm Biomed Anal . 2018 Dec; 165:198-206. PMID: 30553110
Stable isotope labeled (SIL) compounds have been commonly used as internal standards (IS) to ensure the accuracy and quality of liquid chromatography-mass spectrometry (LC-MS) bioanalytical assays. Recently, the application of...
7.
Investigation of the "true" extraction recovery of analytes from multiple types of tissues and its impact on tissue bioanalysis using two model compounds
Yuan L, Ma L, Dillon L, Fancher R, Sun H, Zhu M, et al.
Anal Chim Acta . 2016 Dec; 945:57-66. PMID: 27968716
LC-MS/MS has been widely applied to the quantitative analysis of tissue samples. However, one key remaining issue is that the extraction recovery of analyte from spiked tissue calibration standard and...
8.
Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement
Li W, Zhao W, Liu X, Huang X, Lopez O, Leet J, et al.
Drug Metab Dispos . 2016 Apr; 44(6):809-20. PMID: 27029743
Daclatasvir is a first-in-class, potent, and selective inhibitor of the hepatitis C virus nonstructural protein 5A replication complex. In support of nonclinical studies during discovery and exploratory development, liquid chromatography-tandem...
9.
Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation
Shen H, Liu T, Jiang H, Titsch C, Taylor K, Kandoussi H, et al.
Drug Metab Dispos . 2015 Nov; 44(2):238-49. PMID: 26608080
Organic cation transporter (OCT) 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2K mediate the renal secretion of various cationic drugs and can serve as the loci of drug-drug...
10.
Evaluation of rosuvastatin as an organic anion transporting polypeptide (OATP) probe substrate: in vitro transport and in vivo disposition in cynomolgus monkeys
Shen H, Su H, Liu T, Yao M, Mintier G, Li L, et al.
J Pharmacol Exp Ther . 2015 Mar; 353(2):380-91. PMID: 25740896
Organic anion transporting polypeptides (OATPs) mediate hepatic drug uptake and serve as the loci of drug-drug interactions (DDIs). Consequently, there is a major need to develop animal models and refine...