R M Wightman
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Explore the profile of R M Wightman including associated specialties, affiliations and a list of published articles.
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154
Citations
6630
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Recent Articles
1.
Kirkpatrick D, McKinney C, Manis P, Wightman R
Analyst
. 2016 Jun;
141(16):4902-11.
PMID: 27314130
Multi-modal recording describes the simultaneous collection of information across distinct domains. Compared to isolated measurements, such studies can more easily determine relationships between varieties of phenomena. This is useful for...
2.
Kirkpatrick D, Walton L, Edwards M, Wightman R
Analyst
. 2016 Feb;
141(6):1930-8.
PMID: 26890395
Microiontophoresis is a drug delivery method in which an electric current is used to eject molecular species from a micropipette. It has been primarily utilized for neurochemical investigations, but is...
3.
Masoud S, Vecchio L, Bergeron Y, Hossain M, Nguyen L, Bermejo M, et al.
Neurobiol Dis
. 2014 Dec;
74:66-75.
PMID: 25447236
The dopamine transporter is a key protein responsible for regulating dopamine homeostasis. Its function is to transport dopamine from the extracellular space into the presynaptic neuron. Studies have suggested that...
4.
Budygin E, Park J, Bass C, Grinevich V, Bonin K, Wightman R
Neuroscience
. 2011 Nov;
201:331-7.
PMID: 22108611
Aversive stimuli have a powerful impact on behavior and are considered to be the opposite valence of pleasure. Recent studies have determined some populations of ventral tegmental area (VTA) dopaminergic...
5.
Maus R, McDonald E, Wightman R
Anal Chem
. 2011 Jun;
71(21):4944-50.
PMID: 21662840
The chemiluminescence arising from reaction of electrogenerated radical cations of 9,10-diphenylanthracene (DPA) and benzonitrile (solvent) radical anions has been used to image microelectrodes with dimensions in the micrometer range. Experimental...
6.
Beyene M, Carelli R, Wightman R
Neuroscience
. 2010 Jul;
169(4):1682-8.
PMID: 20600644
The mesolimbic dopamine system is critically involved in modulating reward-seeking behavior and is transiently activated upon presentation of reward-predictive cues. It has previously been shown, using fast-scan cyclic voltammetry in...
7.
Park J, Aragona B, Kile B, Carelli R, Wightman R
Neuroscience
. 2010 May;
169(1):132-42.
PMID: 20451589
Fast-scan cyclic voltammetry (FSCV) at carbon-fiber microelectrodes has been used to demonstrate that sub-second changes in catecholamine concentration occur within the nucleus accumbens (NAc) shell during motivated behaviors, and these...
8.
Hashemi P, Dankoski E, Petrovic J, Keithley R, Wightman R
Anal Chem
. 2009 Oct;
81(22):9462-71.
PMID: 19827792
5-Hydroxytryptamine (5-HT) is an important molecule in the brain that is implicated in mood and emotional processes. In vivo, its dynamic release and uptake kinetics are poorly understood due to...
9.
Heien M, Wightman R
CNS Neurol Disord Drug Targets
. 2006 Apr;
5(1):99-108.
PMID: 16613556
The neurotransmitter dopamine is important in reward processing, however its precise modulatory role is still being investigated. Carbon-fiber microelectrodes can be used to monitor dopamine on a subsecond time scale...
10.
Garris P, Budygin E, Phillips P, Venton B, Robinson D, Bergstrom B, et al.
Neuroscience
. 2003 Apr;
118(3):819-29.
PMID: 12710989
Psychomotor stimulants and neuroleptics exert multiple effects on dopaminergic signaling and produce the dopamine (DA)-related behaviors of motor activation and catalepsy, respectively. However, a clear relationship between dopaminergic activity and...