R M Siegel
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Explore the profile of R M Siegel including associated specialties, affiliations and a list of published articles.
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68
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2492
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Recent Articles
11.
Siegel R, Chan F, Zacharias D, Swofford R, Holmes K, Tsien R, et al.
Sci STKE
. 2001 Dec;
2000(38):pl1.
PMID: 11752595
Many signal transduction pathways operate through oligomerization of proteins into multi-subunit complexes. Although biochemical assays can identify potential protein-protein interactions, studying these interactions in living cells is more challenging. Fluorescence...
12.
Siegel R, Read H
Neural Netw
. 2001 Oct;
14(6-7):697-713.
PMID: 11665764
Cerebral cortex has a range of interconnected functional architectures. Some appear random and without structure, while others are geometrical. Although the biological details certainly constrain spatial temporal patterns in neural...
13.
Bleesing J, Brown M, Straus S, DALE J, Siegel R, Johnson M, et al.
Blood
. 2001 Oct;
98(8):2466-73.
PMID: 11588044
Autoimmune lymphoproliferative syndrome (ALPS) type Ia is caused by inherited defects in apoptosis and is characterized by nonmalignant lymphoaccumulation, autoimmunity, and increased alpha/beta(+) double-negative T cells (alpha/beta(+)-DNT cells). This study...
14.
Chan F, Siegel R, Zacharias D, Swofford R, Holmes K, Tsien R, et al.
Cytometry
. 2001 Aug;
44(4):361-8.
PMID: 11500853
Background: Fluorescence resonance energy transfer (FRET) is a powerful technique for measuring molecular interactions at Angstrom distances. We present a new method for FRET that utilizes the unique spectral properties...
15.
Erickson M, Hill T, Siegel R
Pediatrics
. 2001 Jul;
108(1):98-102.
PMID: 11433060
Objective: By surveying practitioners in our community, we hoped to determine what pediatricians and family physicians (FPs) perceive as barriers to the American Academy of Pediatrics (AAP) Recommendation on Domestic...
16.
Siegel R, Lenardo M
Nat Immunol
. 2001 Jun;
2(7):577-8.
PMID: 11429537
BLyS and family are known to affect B cells in a positive fashion. Knock-outs of BLyS receptors indicate some new functions, including negative regulation by one BLyS receptor, TACI.
17.
Fleisher T, Puck J, Strober W, DALE J, Lenardo M, Siegel R, et al.
Clin Rev Allergy Immunol
. 2001 Mar;
20(1):109-20.
PMID: 11269222
No abstract available.
18.
Siegel R, Chan F, Chun H, Lenardo M
Nat Immunol
. 2001 Mar;
1(6):469-74.
PMID: 11101867
Originally identified as a cell surface receptor that triggered the death of lymphocytes and tumor cells, it is now recognized that Fas (also known as CD95 or Apo-I) has distinct...
19.
Siegel R, Frederiksen J, Zacharias D, Chan F, Johnson M, Lynch D, et al.
Science
. 2000 Jul;
288(5475):2354-7.
PMID: 10875918
Heterozygous mutations encoding abnormal forms of the death receptor Fas dominantly interfere with Fas-induced lymphocyte apoptosis in human autoimmune lymphoproliferative syndrome. This effect, rather than depending on ligand-induced receptor oligomerization,...
20.
Chan F, Chun H, Zheng L, Siegel R, Bui K, Lenardo M
Science
. 2000 Jul;
288(5475):2351-4.
PMID: 10875917
A conserved domain in the extracellular region of the 60- and 80-kilodalton tumor necrosis factor receptors (TNFRs) was identified that mediates specific ligand-independent assembly of receptor trimers. This pre-ligand-binding assembly...