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R M Siegel

Explore the profile of R M Siegel including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 68
Citations 2492
Followers 0
Related Specialties
Neurology
Science
Allergy & Immunology
Top 10 Co-Authors
M J Lenardo
M I Greene
K Yui
F K Chan
R A Andersen
M Katsumata
H L Read
T D Hill
L Zheng
R C Baker
Published In
Proc Natl Acad Sci U S A
Pediatrics
Cereb Cortex
Clin Pediatr (Phila)
Am J Cardiol
Affiliations
Soon will be listed here.
Recent Articles
1.
Natural killer cell expression of Ki67 is associated with elevated serum IL-15, disease activity and nephritis in systemic lupus erythematosus
Hudspeth K, Wang S, Wang J, Rahman S, Smith M, Casey K, et al.
Clin Exp Immunol . 2019 Jan; 196(2):226-236. PMID: 30693467
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder whose pathology involves multiple immune cell types, including B and T lymphocytes as well as myeloid cells. While it is clear...
2.
Factors associated with long-term weight-loss maintenance following bariatric surgery in adolescents with severe obesity
Ryder J, Gross A, Fox C, Kaizer A, Rudser K, Jenkins T, et al.
Int J Obes (Lond) . 2017 Sep; 42(1):102-107. PMID: 28894289
Background/objectives: Bariatric surgery produces robust weight loss, however, factors associated with long-term weight-loss maintenance among adolescents undergoing Roux-en-Y gastric bypass surgery are unknown. Subjects/methods: Fifty adolescents (mean±s.d. age and body...
3.
The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells
Meylan F, Hawley E, Barron L, Barlow J, Penumetcha P, Pelletier M, et al.
Mucosal Immunol . 2013 Dec; 7(4):958-68. PMID: 24368564
The tumor necrosis factor (TNF)-family cytokine TL1A (TNFSF15) costimulates T cells and promotes diverse T cell-dependent models of autoimmune disease through its receptor DR3. TL1A polymorphisms also confer susceptibility to...
4.
The perception of structure from visual motion in monkey and man
Siegel R, Andersen R
J Cogn Neurosci . 2013 Aug; 2(4):306-19. PMID: 23964757
The ability to perceive structure using motion information was examined using a reaction time task with two primate species. Homo sapien and Macaca mulatta subjects were quantitatively tested under identical...
5.
Development of IgA nephropathy-like glomerulonephritis associated with Wiskott-Aldrich syndrome protein deficiency
Shimizu M, Nikolov N, Ueno K, Ohta K, Siegel R, Yachie A, et al.
Clin Immunol . 2011 Nov; 142(2):160-6. PMID: 22079330
Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder caused by mutations in the WAS gene. Glomerulonephritis is a frequent complication, however, histopathological data from affected patients is scarce because the...
6.
Specific elimination of effector memory CD4+ T cells due to enhanced Fas signaling complex formation and association with lipid raft microdomains
Ramaswamy M, Cruz A, Cleland S, Deng M, Price S, Rao V, et al.
Cell Death Differ . 2010 Dec; 18(4):712-20. PMID: 21164519
Elimination of autoreactive CD4(+) T cells through the death receptor Fas/CD95 is an important mechanism of immunological self-tolerance. Fas deficiency results in systemic autoimmunity, yet does not affect the kinetics...
7.
The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation
Meylan F, Song Y, Fuss I, Villarreal S, Kahle E, Malm I, et al.
Mucosal Immunol . 2010 Oct; 4(2):172-85. PMID: 20980995
The tumor necrosis factor (TNF)-family cytokine TL1A (TNFSF15) costimulates T cells through its receptor DR3 (TNFRSF25) and is required for autoimmune pathology driven by diverse T-cell subsets. TL1A has been...
8.
Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis
Muppidi J, Lobito A, Ramaswamy M, Yang J, Wang L, Wu H, et al.
Cell Death Differ . 2006 Jan; 13(10):1641-50. PMID: 16410793
Death receptors in the TNF receptor superfamily signal for apoptosis via the ordered recruitment of FADD and caspase-8 to a death-inducing signaling complex (DISC). However, the nature of the protein-protein...
9.
Cell responsiveness in macaque superior temporal polysensory area measured by temporal discriminants
Turner J, Anderson K, Siegel R
Neural Comput . 2003 Sep; 15(9):2067-90. PMID: 12959666
The firing-rate data from 341 cells from two macaques' superion temporal polysensory area (STPa) were subjected to three different analyses to determine the temporal firing-rate patterns in response to visual...
10.
Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor
PASSER B, Pellegrini L, Russo C, Siegel R, Lenardo M, Schettini G, et al.
J Alzheimers Dis . 2002 Sep; 2(3-4):289-301. PMID: 12214090
The amyloid beta protein precursor (AbetaPP) is sequentially processed by beta- and gamma-secretases to generate the Abeta peptide. The biochemical path leading to Abeta formation has been extensively studied since...