R Luise Krauth-Siegel
Overview
Explore the profile of R Luise Krauth-Siegel including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
87
Citations
1282
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Gonzalez-Gonzalez A, Sanchez-Sanchez O, Krauth-Siegel R, Bolognesi M, Gmez-Escobedo R, Nogueda-Torres B, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36362102
American trypanosomiasis is a worldwide health problem that requires attention due to ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1,4-di--oxide derivatives against trypomastigotes of the strains NINOA and...
2.
Uth J, Borgel F, Lehmkuhl K, Schepmann D, Kaiser M, Jabor V, et al.
J Med Chem
. 2021 Apr;
64(9):6397-6409.
PMID: 33901399
Herein, relationships between the structures of 1-aminoethyl-substituted chromenes and their antimalarial activities were thoroughly investigated. At first, the methyl moiety in the side chain was removed to eliminate chirality. The...
3.
Bogacz M, Dirdjaja N, Wimmer B, Habich C, Krauth-Siegel R
Redox Biol
. 2020 May;
34:101547.
PMID: 32388269
Hydroperoxide reduction in African trypanosomes relies on 2-Cys-peroxiredoxins (Prxs) and glutathione peroxidase-type enzymes (Pxs) which both obtain their reducing equivalents from the trypanothione/tryparedoxin couple and thus act as tryparedoxin peroxidases....
4.
Ebersoll S, Bogacz M, Gunter L, Dick T, Krauth-Siegel R
Elife
. 2020 Feb;
9.
PMID: 32003744
Trypanosomes have a trypanothione redox metabolism that provides the reducing equivalents for numerous essential processes, most being mediated by tryparedoxin (Tpx). While the biosynthesis and reduction of trypanothione are cytosolic,...
5.
Lenz M, Krauth-Siegel R, Schmidt T
Molecules
. 2019 Oct;
24(20).
PMID: 31623252
In the course of our investigations on the antitrypanosomal potential of sesquiterpene lactones (STL), we have recently reported on the exceptionally strong activity of 4,15--Atriplicolide tiglate, which demonstrated an IC...
6.
Currier R, Ulrich K, Leroux A, Dirdjaja N, Deambrosi M, Bonilla M, et al.
PLoS Pathog
. 2019 Sep;
15(9):e1008065.
PMID: 31557263
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved cysteine residues to catalyze thiol-disulfide exchange reactions. Here we demonstrate that the so far unexplored Trx2 from...
7.
De Gasparo R, Halgas O, Harangozo D, Kaiser M, Pai E, Krauth-Siegel R, et al.
Chemistry
. 2019 Aug;
25(49):11416-11421.
PMID: 31407832
Trypanothione reductase (TR) plays a key role in the unique redox metabolism of trypanosomatids, the causative agents of human African trypanosomiasis (HAT), Chagas' disease, and leishmaniases. Introduction of a new,...
8.
Wagner A, Le T, Brennich M, Klein P, Bader N, Diehl E, et al.
Angew Chem Int Ed Engl
. 2019 Jan;
58(11):3640-3644.
PMID: 30605929
Trypanosomal and leishmanial infections claim tens of thousands of lives each year. The metabolism of these unicellular eukaryotic parasites differs from the human host and their enzymes thus constitute promising...
9.
Bogacz M, Krauth-Siegel R
Elife
. 2018 Jul;
7.
PMID: 30047863
Tryparedoxin peroxidases, distant relatives of glutathione peroxidase 4 in higher eukaryotes, are responsible for the detoxification of lipid-derived hydroperoxides in African trypanosomes. The lethal phenotype of procyclic that lack the...
10.
De Gasparo R, Brodbeck-Persch E, Bryson S, Hentzen N, Kaiser M, Pai E, et al.
ChemMedChem
. 2018 Apr;
13(9):957-967.
PMID: 29624890
The tropical diseases human African trypanosomiasis, Chagas disease, and the various forms of leishmaniasis are caused by parasites of the family of trypanosomatids. These protozoa possess a unique redox metabolism...