R L Matts
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Explore the profile of R L Matts including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
626
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Recent Articles
1.
Scholz G, Hartson S, Cartledge K, Volk L, Matts R, Dunn A
Cell Growth Differ
. 2001 Aug;
12(8):409-17.
PMID: 11504706
We have investigated the relationship between the molecular chaperone heat shock protein-90 (Hsp90) and the signal transducing capacity of the Src-family kinase Hck. Inhibition of Hsp90 with geldanamycin suppressed the...
2.
Uma S, Yun B, Matts R
J Biol Chem
. 2001 Mar;
276(18):14875-83.
PMID: 11278914
Nitric oxide (NO) has been reported to inhibit protein synthesis in eukaryotic cells by increasing the phosphorylation of the alpha-subunit of eukaryotic initiation factor (eIF) 2. However, the mechanism through...
3.
Shao J, Grammatikakis N, Scroggins B, Uma S, Huang W, Chen J, et al.
J Biol Chem
. 2000 Oct;
276(1):206-14.
PMID: 11036079
Recent studies indicate that p50(cdc37) facilitates Hsp90-mediated biogenesis of certain protein kinases. In this report, we examined whether p50(cdc37) is required for the biogenesis of the heme-regulated eIF2 alpha kinase...
4.
Scholz G, Hartson S, Cartledge K, Hall N, Shao J, Dunn A, et al.
Mol Cell Biol
. 2000 Aug;
20(18):6984-95.
PMID: 10958693
Genetic studies have previously revealed that Cdc37p is required for the catalytic competence of v-Src in yeast. We have reasoned that temperature-sensitive mutants of Src family kinases might be more...
5.
Hartson S, Irwin A, Shao J, Scroggins B, Volk L, Huang W, et al.
Biochemistry
. 2000 Jun;
39(25):7631-44.
PMID: 10858314
Hsp90 and p50(cdc37) provide a poorly understood biochemical function essential to certain protein kinases, and recent models describe p50(cdc37) as an exclusive hsp90 cohort which links hsp90 machinery to client...
6.
Marissen W, Guo Y, Thomas A, Matts R, Lloyd R
J Biol Chem
. 2000 Mar;
275(13):9314-23.
PMID: 10734073
Induction of apoptosis in a variety of cell types leads to inhibition of protein synthesis. Recently, the cleavage of eukaryotic translation initiation factor 4G (eIF4G) by caspase 3 was described...
7.
Yorgin P, Hartson S, Fellah A, Scroggins B, Huang W, Katsanis E, et al.
J Immunol
. 2000 Mar;
164(6):2915-23.
PMID: 10706677
The benzoquinoid ansamycins geldanamycin (GA), herbimycin, and their derivatives are emerging as novel therapeutic agents that act by inhibiting the 90-kDa heat-shock protein hsp90. We report that GA inhibits the...
8.
Chefalo P, Hussain Z, Hahn J, Uma S, Matts R, Chen J
J Biol Chem
. 2000 Feb;
275(7):5171-8.
PMID: 10671563
In heme deficiency, protein synthesis in reticulocytes is inhibited by activation of heme-regulated alpha-subunit of eukaryotic initiation factor-2alpha (eIF-2alpha) kinase (HRI). Previous studies indicate that HRI contains two distinct heme-binding...
9.
Uma S, Matts R, Guo Y, White S, Chen J
Eur J Biochem
. 2000 Jan;
267(2):498-506.
PMID: 10632719
The N-terminal domain (NTD) of the heme-regulated eukaryotic initiation factor (eIF)2alpha kinase (HRI) was aligned to sequences in the NCBI data base using ENTREZ and a PAM250 matrix. Significant similarity...
10.
Uma S, Thulasiraman V, Matts R
Mol Cell Biol
. 1999 Aug;
19(9):5861-71.
PMID: 10454533
The heme-regulated kinase of the alpha subunit of eukaryotic initiation factor 2 (HRI) is activated in rabbit reticulocyte lysate (RRL) in response to a number of environmental conditions, including heme...