R Kole
Overview
Explore the profile of R Kole including associated specialties, affiliations and a list of published articles.
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Articles
60
Citations
1737
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Recent Articles
1.
Vacek M, Sazani P, Kole R
Cell Mol Life Sci
. 2003 Jun;
60(5):825-33.
PMID: 12827272
Antisense technology has been used to study basic biological processes, and to block these processes when they deleteriously lead to human disease. A separate, equally important application of antisense technology...
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Mercatante D, Sazani P, Kole R
Curr Cancer Drug Targets
. 2002 Aug;
1(3):211-30.
PMID: 12188880
It has been estimated that greater than 35% of all human genes undergo alternative splicing. The process of alternative splicing is highly regulated and disruption of a splicing pattern can...
4.
Gemignani F, Landi S, DeMarini D, Kole R
Hum Mutat
. 2001 Dec;
18(6):526-34.
PMID: 11748845
A HeLa cell line stably expressing the enhanced green fluorescence protein (EGFP) gene, interrupted by the HBB IVS2-654 intron, was studied without treatment and after treatment with a single standard...
5.
Sazani P, Kang S, Maier M, Wei C, Dillman J, Summerton J, et al.
Nucleic Acids Res
. 2001 Sep;
29(19):3965-74.
PMID: 11574678
The antisense activity of oligomers with 2'-O-methyl (2'-O-Me) phosphorothioate, 2'-O-methoxyethyl (2'-O-MOE) phosphorothioate, morpholino and peptide nucleic acid (PNA) backbones was investigated using a splicing assay in which the modified oligonucleotides...
6.
Kole R, Sazani P
Curr Opin Mol Ther
. 2001 Aug;
3(3):229-34.
PMID: 11497345
The surprisingly small number of human genes, which has recently been estimated to be approximately 30,000, suggests that RNA processing, and in particular alternative RNA splicing, is in large part...
7.
Tian H, Kole R
J Biol Chem
. 2001 Jul;
276(36):33833-9.
PMID: 11454855
A modified method of cycled selection was used to characterize splicing enhancers for exon inclusion from a pool of beta-globin-based three exon/two intron pre-mRNAs with a variable number of random...
8.
Mercatante D, Bortner C, Cidlowski J, Kole R
J Biol Chem
. 2001 Mar;
276(19):16411-7.
PMID: 11278482
There is ample evidence that deregulation of apoptosis results in the development, progression, and/or maintenance of cancer. Since many apoptotic regulatory genes (e.g. bcl-x) code for alternatively spliced protein variants...
9.
Gorman L, Mercatante D, Kole R
J Biol Chem
. 2000 Sep;
275(46):35914-9.
PMID: 10969081
The T-->G mutation at nucleotide 705 in the second intron of the beta-globin gene creates an aberrant 5' splice site and activates a 3' cryptic splice site upstream from the...
10.
Lacerra G, Sierakowska H, Carestia C, Fucharoen S, Summerton J, Weller D, et al.
Proc Natl Acad Sci U S A
. 2000 Aug;
97(17):9591-6.
PMID: 10944225
Mononuclear cells from peripheral blood of thalassemic patients were treated with morpholino oligonucleotides antisense to aberrant splice sites in mutant beta-globin precursor mRNAs (pre-mRNAs). The oligonucleotides restored correct splicing and...