R Kircheis
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Explore the profile of R Kircheis including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
862
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Recent Articles
1.
Nechansky A, Szolar O, Siegl P, Zinoecker I, Halanek N, Wiederkum S, et al.
J Pharm Biomed Anal
. 2009 Mar;
49(4):1014-20.
PMID: 19250790
The fully humanized Lewis-Y carbohydrate specific monoclonal antibody (mAb) IGN311 is currently tested in a passive immunotherapy approach in a clinical phase I trail and therefore regulatory requirements demand qualified...
2.
Smrekar B, Wightman L, Wolschek M, Lichtenberger C, Ruzicka R, Ogris M, et al.
Gene Ther
. 2003 Jun;
10(13):1079-88.
PMID: 12808438
Systemic application of surface-shielded transferrin-polyethylenimine/DNA complexes leads to predominant DNA uptake and gene expression in Neuro2a tumors in syngeneic A/J mice. Similarly, high expression levels were found in Huh-7 and...
3.
Gharwan H, Wightman L, Kircheis R, Wagner E, Zatloukal K
Gene Ther
. 2003 Apr;
10(9):810-7.
PMID: 12704421
We investigated the efficacy and safety of the cationic polymer polyethylenimine (PEI) as a potential tool for intrauterine gene delivery into livers of fetal mice in the last trimester of...
4.
Kircheis R, Wightman L, Kursa M, Ostermann E, Wagner E
Gene Ther
. 2002 May;
9(11):731-5.
PMID: 12032698
We have developed surface-shielded ligand-polycation based gene delivery systems which are able to target gene expression to distant tumors after systemic application. Tumor-specific targeting is achieved by (1) incorporation of...
5.
Kircheis R, Wightman L, Wagner E
Adv Drug Deliv Rev
. 2001 Dec;
53(3):341-58.
PMID: 11744176
The polycation polyethylenimine (PEI) has recently been widely employed for the design of DNA delivery vehicles. Gene delivery using PEI involves condensation of DNA into compact particles, uptake into the...
6.
Wightman L, Kircheis R, Rossler V, Carotta S, Ruzicka R, Kursa M, et al.
J Gene Med
. 2001 Sep;
3(4):362-72.
PMID: 11529666
Background: Efficient gene transfer is a major challenge for non-viral gene therapy. Understanding how non-viral vectors initiate gene expression could lead to the development of new future vectors with enhanced...
7.
Blessing T, Kursa M, Holzhauser R, Kircheis R, Wagner E
Bioconjug Chem
. 2001 Jul;
12(4):529-37.
PMID: 11459457
With the aim of generating gene delivery systems for tumor targeting, we have synthesized a conjugate consisting of polyethylenimine (PEI) covalently modified with epidermal growth factor (EGF) peptides. Transfection efficiency...
8.
Felzmann T, Buchberger M, Lehner M, Printz D, Kircheis R, Wagner E, et al.
Cancer Lett
. 2001 Jun;
168(2):145-54.
PMID: 11403919
Tumor antigen pulsed dendritic cells (DCs) can induce anti-tumor immunity. We studied strategies for the reliable generation of such a tumor vaccine by functional maturation of DCs via interaction of...
9.
Kircheis R, Wightman L, Schreiber A, Robitza B, Rossler V, Kursa M, et al.
Gene Ther
. 2001 Jun;
8(1):28-40.
PMID: 11402299
Systemic application of positively charged polycation/DNA complexes has been shown to result in predominant gene expression in the lungs. Targeting gene expression to other sites, eg distant tumors, is hampered...
10.
Kircheis R, Blessing T, Brunner S, Wightman L, Wagner E
J Control Release
. 2001 Jun;
72(1-3):165-70.
PMID: 11389995
Incorporation of the receptor binding ligands transferrin (Tf) or epidermal growth factor (EGF) into DNA/polyethylenimine (PEI) complexes was found to enhance gene transfer into tumor cell lines in a receptor-dependent...