R Keira Cheetham
Overview
Explore the profile of R Keira Cheetham including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
5084
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Recent Articles
1.
Murali R, Selenica P, Brown D, Cheetham R, Chandramohan R, Claros N, et al.
Histopathology
. 2018 Dec;
74(4):638-650.
PMID: 30565721
Aims: Low-grade serous carcinomas (LGSCs) and their precursors serous borderline tumours (SBTs) characteristically harbour mutations in BRAF, KRAS or NRAS but rarely in TP53, whereas high-grade serous carcinomas (HGSCs) are...
2.
Quigley D, Dang H, Zhao S, Lloyd P, Aggarwal R, Alumkal J, et al.
Cell
. 2018 Oct;
175(3):889.
PMID: 30340047
No abstract available.
3.
Quigley D, Dang H, Zhao S, Lloyd P, Aggarwal R, Alumkal J, et al.
Cell
. 2018 Jul;
174(3):758-769.e9.
PMID: 30033370
While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101...
4.
Ross-Innes C, Becq J, Warren A, Cheetham R, Northen H, ODonovan M, et al.
Nat Genet
. 2015 Jul;
47(9):1038-1046.
PMID: 26192915
The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's esophagus, is poorly understood. Using whole-genome sequencing on 23 paired Barrett's esophagus and EAC samples, together with...
5.
Chien J, Sicotte H, Fan J, Humphray S, Cunningham J, Kalli K, et al.
Nucleic Acids Res
. 2015 Apr;
43(14):6945-58.
PMID: 25916844
To determine early somatic changes in high-grade serous ovarian cancer (HGSOC), we performed whole genome sequencing on a rare collection of 16 low stage HGSOCs. The majority showed extensive structural...
6.
Leonard B, Hart S, Burns M, Carpenter M, Temiz N, Rathore A, et al.
Cancer Res
. 2013 Oct;
73(24):7222-31.
PMID: 24154874
Ovarian cancer is a clinically and molecularly heterogeneous disease. The driving forces behind this variability are unknown. Here, we report wide variation in the expression of the DNA cytosine deaminase...
7.
Saunders C, Wong W, Swamy S, Becq J, Murray L, Cheetham R
Bioinformatics
. 2012 May;
28(14):1811-7.
PMID: 22581179
Motivation: Whole genome and exome sequencing of matched tumor-normal sample pairs is becoming routine in cancer research. The consequent increased demand for somatic variant analysis of paired samples requires methods...
8.
Murchison E, Schulz-Trieglaff O, Ning Z, Alexandrov L, Bauer M, Fu B, et al.
Cell
. 2012 Feb;
148(4):780-91.
PMID: 22341448
The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered due to a transmissible facial cancer spread by direct transfer of living cancer cells through biting. Here we describe...
9.
Mills R, Walter K, Stewart C, Handsaker R, Chen K, Alkan C, et al.
Nature
. 2011 Feb;
470(7332):59-65.
PMID: 21293372
Genomic structural variants (SVs) are abundant in humans, differing from other forms of variation in extent, origin and functional impact. Despite progress in SV characterization, the nucleotide resolution architecture of...
10.
Ivakhno S, Royce T, Cox A, Evers D, Cheetham R, Tavare S
Bioinformatics
. 2010 Oct;
26(24):3051-8.
PMID: 20966003
Motivation: Copy number abnormalities (CNAs) represent an important type of genetic mutation that can lead to abnormal cell growth and proliferation. New high-throughput sequencing technologies promise comprehensive characterization of CNAs....