David Bentley
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Explore the profile of David Bentley including associated specialties, affiliations and a list of published articles.
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64
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7888
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Recent Articles
1.
Cozzolino K, Sanford L, Hunter S, Molison K, Erickson B, Courvan M, et al.
Elife
. 2025 Feb;
13.
PMID: 39928031
Hyperactive interferon (IFN) signaling is a hallmark of Down syndrome (DS), a condition caused by Trisomy 21 (T21); strategies that normalize IFN signaling could benefit this population. Mediator-associated kinases CDK8...
2.
Bishop M, Vedi A, Bowdin S, Armstrong R, Bartram J, Bentley D, et al.
BMC Med Educ
. 2024 Nov;
24(1):1273.
PMID: 39506754
Background: The clinical utility of whole genome sequencing (WGS) in paediatric cancer has been demonstrated in recent years. WGS has been routinely available in the National Health Service (NHS) England...
3.
Blears D, Lou J, Fong N, Mitter R, Sheridan R, He D, et al.
Mol Cell
. 2024 Nov;
84(24):4790-4807.e11.
PMID: 39504960
The biological purpose of Integrator and RNA polymerase II (RNAPII) promoter-proximal pausing remains uncertain. Here, we show that loss of INTS6 in human cells results in increased interaction of RNAPII...
4.
Bentley D, Dura-Vila G
Child Adolesc Ment Health
. 2024 Mar;
29(2):214-216.
PMID: 38494196
No abstract available.
5.
Sosinsky A, Ambrose J, Cross W, Turnbull C, Henderson S, Jones L, et al.
Nat Med
. 2024 Jan;
30(1):279-289.
PMID: 38200255
The Cancer Programme of the 100,000 Genomes Project was an initiative to provide whole-genome sequencing (WGS) for patients with cancer, evaluating opportunities for precision cancer care within the UK National...
6.
Robbe P, Ridout K, Vavoulis D, Dreau H, Kinnersley B, Denny N, et al.
Nat Genet
. 2022 Nov;
54(11):1675-1689.
PMID: 36333502
The value of genome-wide over targeted driver analyses for predicting clinical outcomes of cancer patients is debated. Here, we report the whole-genome sequencing of 485 chronic lymphocytic leukemia patients enrolled...
7.
Ferguson J, Oldmeadow C, Bentley D, Eslick S, Garg M
Complement Ther Med
. 2022 Oct;
71:102896.
PMID: 36280012
Objectives: High blood pressure (BP) is a major risk factor for cardiovascular disease and prevalence rates continue to rise with ageing populations. Polypharmacy remains a burden among the ageing, thus...
8.
Ferguson J, Oldmeadow C, Bentley D, Garg M
Antioxidants (Basel)
. 2022 Aug;
11(8).
PMID: 36009279
Oxidative stress is a key physiological phenomenon underpinning the ageing process and plays a major developmental role in age-associated chronic diseases. This study investigated the antioxidant effects of a polyphenol-rich...
9.
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams C, Walker S, et al.
Nature
. 2022 Mar;
607(7917):97-103.
PMID: 35255492
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of...
10.
Smedley D, Smith K, Martin A, Thomas E, McDonagh E, Cipriani V, et al.
N Engl J Med
. 2021 Nov;
385(20):1868-1880.
PMID: 34758253
Background: The U.K. 100,000 Genomes Project is in the process of investigating the role of genome sequencing in patients with undiagnosed rare diseases after usual care and the alignment of...