R K Prinjha
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Explore the profile of R K Prinjha including associated specialties, affiliations and a list of published articles.
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12
Citations
584
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Recent Articles
1.
Khoueiry P, Ward Gahlawat A, Petretich M, Michon A, Simola D, Lam E, et al.
Epigenetics Chromatin
. 2019 Jul;
12(1):39.
PMID: 31266503
Background: Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene...
2.
Willis V, Banda N, Cordova K, Chandra P, Robinson W, Cooper D, et al.
Clin Exp Immunol
. 2017 Jan;
188(2):263-274.
PMID: 28128853
Citrullination of joint proteins by the protein arginine deiminase (PAD) family of enzymes is recognized increasingly as a key process in the pathogenesis of rheumatoid arthritis. This present study was...
3.
Cruickshank M, Ford J, Cheung L, Heng J, Singh S, Wells J, et al.
Leukemia
. 2016 Jul;
31(1):40-50.
PMID: 27443263
To address the poor prognosis of mixed lineage leukemia (MLL)-rearranged infant acute lymphoblastic leukemia (iALL), we generated a panel of cell lines from primary patient samples and investigated cytotoxic responses...
4.
Dawson M, Gudgin E, Horton S, Giotopoulos G, Meduri E, Robson S, et al.
Leukemia
. 2013 Nov;
28(2):311-20.
PMID: 24220271
Recent evidence suggests that inhibition of bromodomain and extra-terminal (BET) epigenetic readers may have clinical utility against acute myeloid leukemia (AML). Here we validate this hypothesis, demonstrating the efficacy of...
5.
Wyspianska B, Bannister A, Barbieri I, Nangalia J, Godfrey A, Calero-Nieto F, et al.
Leukemia
. 2013 Aug;
28(1):88-97.
PMID: 23929215
Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of mixed lineage...
6.
Prinjha R, Witherington J, Lee K
Trends Pharmacol Sci
. 2012 Jan;
33(3):146-53.
PMID: 22277300
Therapeutic targeting of the processes that regulate histone modification is a growing area of scientific exploration. Although most interest has concentrated on the various families of enzymes that contribute to...
7.
Ishihara-Paul L, Hulihan M, Kachergus J, Upmanyu R, Warren L, Amouri R, et al.
Neurology
. 2008 Aug;
71(12):896-902.
PMID: 18685134
Background: PINK1 loss-of-function causes recessive, early-onset parkinsonism. In Tunisia there is a high rate of consanguineous marriage but PINK1 carrier frequency and disease prevalence have yet to be assessed. Objectives:...
8.
OSBORNE S, Corcoran S, Prinjha R, Moore S
Neurogastroenterol Motil
. 2004 Aug;
16(4):465-74.
PMID: 15306002
Neuronal plasticity plays an important role in physiological and pathological processes within the gastrointestinal (GI) tract. Nogo A is a major contributor to the negative effect central nervous system (CNS)...
9.
Hunt D, Coffin R, Prinjha R, Campbell G, Anderson P
Mol Cell Neurosci
. 2003 Dec;
24(4):1083-102.
PMID: 14697671
The expression of Nogo-A mRNA and protein in the nervous system of adult rats and cultured neurons was studied by in situ hybridisation and immunohistochemistry. Nogo-A mRNA was expressed by...
10.
Gunthorpe M, Harries M, Prinjha R, Davis J, Randall A
J Physiol
. 2000 Jun;
525 Pt 3:747-59.
PMID: 10856126
Whole-cell voltage-clamp techniques were used to investigate the capsaicin-, voltage- and time-dependent properties of the rat vanilloid receptor (rVR1) stably expressed in human embryonic kidney (HEK) 293 cells. At a...