R J Oles
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Explore the profile of R J Oles including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
329
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Recent Articles
1.
Field M, Oles R, Singh L
Br J Pharmacol
. 2001 Jan;
132(1):1-4.
PMID: 11156553
The present study examines the effect of pregabalin (previously S-Isobutylgaba and CI-1008) in two distinct rat models of anxiety. Pregabalin binds with high affinity and selectivity to the alpha(2)delta subunit...
2.
Field M, Carnell A, Gonzalez M, McCleary S, Oles R, Smith R, et al.
Pain
. 1999 Apr;
80(1-2):383-9.
PMID: 10204752
Enadoline is a highly selective and potent kappa-opioid receptor agonist. This report describes and compares the activities of enadoline and morphine in a rat model of postoperative pain. A 1...
3.
Bryans J, Davies N, Gee N, Dissanayake V, Ratcliffe G, Horwell D, et al.
J Med Chem
. 1998 Jun;
41(11):1838-45.
PMID: 9599234
As part of a program to investigate the structure-activity relationships of Gabapentin (Neurontin), a number of alkylated analogues were synthesized and evaluated in vitro for binding to the Gabapentin binding...
4.
Gonzalez M, Field M, Holloman E, Hughes J, Oles R, Singh L
Eur J Pharmacol
. 1998 May;
344(2-3):115-20.
PMID: 9600644
PD 154075 ([(2-benzofuran)-CH2OCO]-(R)-alpha-MeTrp-(S)-NHCH(CH3) Ph) is a selective tachykinin NK1 receptor antagonist. Its effect on development and maintenance of thermal and mechanical hypersensitivity was examined in a rat model of surgical...
5.
Field M, Oles R, Lewis A, McCleary S, Hughes J, Singh L
Br J Pharmacol
. 1997 Aug;
121(8):1513-22.
PMID: 9283683
1. Gabapentin (neurontin) is a novel antiepileptic agent that binds to the alpha 2 delta subunit of voltage-dependent calcium channels. The only other compound known to possess affinity for this...
6.
Singh L, Field M, Ferris P, Hunter J, Oles R, Williams R, et al.
Psychopharmacology (Berl)
. 1996 Sep;
127(1):1-9.
PMID: 8880937
This report describes the activity of the antiepileptic agent gabapentin (Neurontin) in animal models predictive of anxiolysis and analgesia. Gabapentin displayed anxiolytic-like action in the rat conflict test, the mouse...
7.
Singh L, Field M, Hunter J, Oles R, Woodruff G
Eur J Pharmacol
. 1996 Jul;
307(3):283-9.
PMID: 8836616
The ability of a mixed CCKA/B receptor antagonist PD 142898 (benzenebutanic acid, beta-[[3-(1 H-indol-3-yl)-2-methyl-2-[[[(2-methyl- cyclohexyl)oxy]carbonyl]amino]-1-oxopropyl]amino]-[1 S-[1 alpha [S*(R*)]-2 beta]]) to modulate the antinociceptive, positive reinforcing and gastrointestinal actions of morphine...
8.
Singh L, Oles R, Field M, Atwal P, Woodruff G, Hunter J
Br J Pharmacol
. 1996 Jul;
118(5):1317-25.
PMID: 8818359
1. The ability of a selective CCKA receptor antagonist PD 140548 and a selective CCKB receptor antagonist CI-988 (formerly PD 134308) to modulate the various in vivo properties of morphine...
9.
Singh L, Field M, Hughes J, Menzies R, Oles R, Vass C, et al.
Br J Pharmacol
. 1991 Sep;
104(1):239-45.
PMID: 1686205
1. The behavioural effects of a selective cholecystokininB (CCKB) receptor antagonist CI-988 were investigated in rodents. 2. In three rodent tests of anxiety (rat elevated X-maze, rat social interaction test...
10.
Tricklebank M, Singh L, Jackson A, Oles R
Brain Res
. 1991 Aug;
558(1):145-8.
PMID: 1657311
Lithium inhibits myo-inositol mono- and polyphosphatase activity in brain at concentrations similar to those optimal for the treatment of manic depressive psychosis. A consequence of this inhibition is the possibility...