R J Laib
Overview
Explore the profile of R J Laib including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
45
Citations
236
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Csandy G, Laib R, Filser J
Toxicol Lett
. 1995 Jan;
75(1-3):217-23.
PMID: 7863530
Olefinic hydrocarbons are metabolized in vivo by cytochrome P450-dependent monooxygenases to the corresponding epoxides. The maximum in vivo metabolic rate, which is an important toxicokinetic parameter, has been used to...
2.
Vangala R, Laib R, Bolt H
Arch Toxicol
. 1993 Jan;
67(1):34-8.
PMID: 8452477
The alkaline filter elution technique was used to evaluate single strand breaks (SSB), DNA-DNA (DDCL) and DNA-protein cross-links (DPCL) in liver and lung of male rats (Sprague-Dawley) and male mice...
3.
Laib R, Tucholski M, Filser J, Csanady G
Arch Toxicol
. 1992 Jan;
66(5):310-4.
PMID: 1610292
Gas uptake studies were carried out to evaluate kinetic interactions between 1,3-butadiene and styrene in Sprague-Dawley rats. The animals were co-exposed by inhalation to a mixture of 1,3-butadiene between 20...
4.
Investigation of species differences in isobutene (2-methylpropene) metabolism between mice and rats
Csanady G, Freise D, Denk B, Filser J, Cornet M, Rogiers V, et al.
Arch Toxicol
. 1991 Jan;
65(2):100-5.
PMID: 2059150
Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for...
5.
Cornet M, Sonck W, Callaerts A, CSANADY G, Vercruysse A, Laib R, et al.
Arch Toxicol
. 1991 Jan;
65(4):263-7.
PMID: 1953344
Until now, no data are available concerning the biotransformation and toxicity of 2-methylpropene (or isobutene), a gaseous alkene widely used in industry (rubber, fuel additives, plastic polymers, adhesives, antioxidants). In...
6.
Peter H, Wiegand H, Filser J, Bolt H, Laib R
Environ Health Perspect
. 1990 Jun;
86:89-92.
PMID: 2401276
Studies on inhalation pharmacokinetics of isoprene were conducted in rats (Wistar) and mice (B6C3F1) to investigate possible species differences in metabolism of this compound. Pharmacokinetic analysis of isoprene inhaled by...
7.
Laib R, Filser J, Kreiling R, Vangala R, Bolt H
Environ Health Perspect
. 1990 Jun;
86:57-63.
PMID: 2401272
Studies were conducted on inhalation pharmacokinetics of 1,3-butadiene and of its primary reactive metabolic intermediate 1,2-epoxybutene-3 in rats (Sprague-Dawley) and mice (B6C3F1). Investigations of inhalation pharmacokinetics of 1,3-butadiene revealed saturation...
8.
Ristau C, Deutschmann S, Laib R, Ottenwalder H
Arch Toxicol
. 1990 Jan;
64(4):343-4.
PMID: 2386432
No abstract available.
9.
Csanady G, Laib R
Arch Toxicol
. 1990 Jan;
64(7):594-6.
PMID: 2073134
A relationship between the partition coefficient (P) and the boiling point (TBp, expressed in degrees Kelvin) was derived as TBp = alpha *ln(P) + beta. The relationship is based on...
10.
Laib R, Bolt H, Cartier R, Bartsch H
Toxicol Lett
. 1989 Feb;
45(2-3):231-9.
PMID: 2919404
To investigate the factors responsible for the high sensitivity of the livers of young rats to the carcinogenic stimulus of vinyl chloride (VC) adult and 11-day-old Wistar rats were exposed...