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R J Kimple

Explore the profile of R J Kimple including associated specialties, affiliations and a list of published articles. Areas
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Articles 4
Citations 335
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Recent Articles
1.
Brower J, Amini A, Chen S, Hullett C, Kimple R, Wojcieszynski A, et al.
Ann Oncol . 2016 Aug; 27(10):1887-94. PMID: 27502703
Background: Concurrent chemoradiation is the standard of care in non-operable stage III non-small-cell lung cancer (NSCLC). Data have suggested a benefit of dose escalation; however, results from the randomized dose-escalation...
2.
Adams A, Hallenbeck G, Casper K, Patil Y, Wilson K, Kimple R, et al.
Oncogene . 2014 Mar; 34(7):868-77. PMID: 24608431
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, and patient outcomes using current treatments remain poor. Tumor development is etiologically associated with tobacco or...
3.
McCudden C, Hains M, Kimple R, Siderovski D, Willard F
Cell Mol Life Sci . 2005 Mar; 62(5):551-77. PMID: 15747061
Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs). GPCRs act on inactive Galpha.GDP/Gbetagamma heterotrimers to promote GDP release and GTP binding, resulting in liberation of Galpha from Gbetagamma. Galpha.GTP...
4.
Kimple R, de Vries L, Tronchere H, Behe C, Morris R, Gist Farquhar M, et al.
J Biol Chem . 2001 Jun; 276(31):29275-81. PMID: 11387333
The regulators of G-protein signaling (RGS) proteins accelerate the intrinsic guanosine triphosphatase activity of heterotrimeric G-protein alpha subunits and are thus recognized as key modulators of G-protein-coupled receptor signaling. RGS12...