R J Fleming
Overview
Explore the profile of R J Fleming including associated specialties, affiliations and a list of published articles.
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34
Citations
640
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Recent Articles
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2.
Ratan R, Mason D, Sinnot B, Goldfarb D, Fleming R
Genetics
. 2008 Feb;
178(2):839-50.
PMID: 18245351
Importin alpha's mediate nuclear transport by linking nuclear localization signal (NLS)-containing proteins to importin beta1. Animal genomes encode three conserved groups of importin alpha's, alpha1's, alpha2's, and alpha3's, each of...
3.
Fleming R, Purcell K, Artavanis-Tsakonas S
Trends Cell Biol
. 2007 Aug;
7(11):437-41.
PMID: 17709001
An intricate interplay of signalling pathways dictates the acquisition of specific cell fates during development. The NOTCH receptor is the central element in a cell-interaction mechanism that controls the fate...
4.
Fleming R
Semin Cell Dev Biol
. 1999 Jan;
9(6):599-607.
PMID: 9918871
The Notch signalling pathway is an evolutionarily conserved cell-to-cell communication system utilized multiple times and in many tissues during development. The outcome of an interaction between Notch and its ligands...
5.
Hukriede N, Gu Y, Fleming R
Development
. 1997 Oct;
124(17):3427-37.
PMID: 9310337
Specification of the dorsal-ventral compartment boundary in the developing Drosophila wing disc requires activation of NOTCH from its dorsal ligand SERRATE and its ventral ligand DELTA. Both NOTCH ligands are...
6.
Fleming R, Gu Y, Hukriede N
Development
. 1997 Aug;
124(15):2973-81.
PMID: 9247339
In the developing imaginal wing disc of Drosophila, cells at the dorsoventral boundary require localized Notch activity for specification of the wing margin. The Notch ligands Serrate and Delta are...
7.
Hukriede N, Fleming R
Genetics
. 1997 Feb;
145(2):359-74.
PMID: 9071590
Serrate (Ser) is an essential gene in Drosophila melanogaster best known for the Ser dominant (SerD) allele and its effects on wing development. Animals heterozygous or homozygous for SerD are...
8.
Gu Y, Hukriede N, Fleming R
Development
. 1995 Mar;
121(3):855-65.
PMID: 7720588
Serrate and Delta encode structurally related proteins in D. melanogaster that bind within a common extracellular region on the NOTCH receptor molecule. We used ectopic expression to determine if SERRATE...
9.
Rebay I, Fleming R, Fehon R, Cherbas L, Cherbas P, Artavanis-Tsakonas S
Cell
. 1991 Nov;
67(4):687-99.
PMID: 1657403
The neurogenic loci Notch and Delta, which both encode EGF-homologous transmembrane proteins, appear to function together in mediating cell-cell communication and have been shown to interact at the cell surface...
10.
Fleming R, Scottgale T, Diederich R, Artavanis-Tsakonas S
Genes Dev
. 1990 Dec;
4(12A):2188-201.
PMID: 2125287
Mutations in the third chromosome gene Serrate are shown to display genetic interactions with specific alleles of the neurogenic locus Notch, which encodes a transmembrane protein with epidermal growth factor...