R J Auchus
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Explore the profile of R J Auchus including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
749
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Recent Articles
1.
Capper C, Liu J, McIntosh L, Larios J, Johnson M, Hollenberg P, et al.
J Steroid Biochem Mol Biol
. 2017 Dec;
178:159-166.
PMID: 29229304
Cytochrome P450 17A1 (CYP17A1) is a dual-function enzyme catalyzing reactions necessary for cortisol and androgen biosynthesis. CYP17A1 is a validated drug target for prostate cancer as CYP17A1 inhibition significantly reduces...
2.
Miller B, Turcu A, Nanba A, Hughes D, Cohen M, Gauger P, et al.
World J Surg
. 2017 Nov;
42(2):453-463.
PMID: 29134312
Introduction: Determination of outcomes after adrenalectomy for primary aldosteronism (PA) is limited by the lack of standardized definitions of cure. The Primary Aldosteronism Surgical Outcomes (PASO) group recently established new...
3.
Auchus R, Quint E
Horm Metab Res
. 2015 Mar;
47(5):367-74.
PMID: 25750080
Children with chronic illnesses face multiple challenges as they mature into adulthood, which relate to independence, access to care, and changes in care providers. The scope and magnitude of these...
4.
Noori S, McNamara P, Jain A, Lavoie P, Wickremasinghe A, Merritt T, et al.
J Perinatol
. 2014 Aug;
35(2):123-7.
PMID: 25118721
Objective: We performed a multicenter study of preterm infants, who were about to undergo patent ductus arteriosus ligation, to determine whether echocardiographic indices of impaired myocardial performance were associated with...
5.
Auchus R, Wians Jr F, Anderson M, Dolmatch B, Trimmer C, Josephs S, et al.
Horm Metab Res
. 2010 Apr;
42(6):411-5.
PMID: 20411476
During the last two decades, primary aldosteronism has emerged as the most common cause of secondary hypertension, and advances in the diagnosis and treatment of this condition have improved patient...
6.
Miyoshi Y, Akagi M, Agarwal A, Namba N, Kato-Nishimura K, Mohri I, et al.
Clin Genet
. 2008 Apr;
73(6):535-44.
PMID: 18435794
Mandibuloacral dysplasia (MAD) is a rare autosomal recessive progeroid syndrome, characterized by mandibular hypoplasia, acroosteolysis affecting distal phalanges and clavicles, delayed closure of the cranial sutures, atrophic skin, and lipodystrophy....
7.
Auchus R, Geller D, Lee T, Miller W
Trends Endocrinol Metab
. 2008 Apr;
9(2):47-50.
PMID: 18406239
The polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and insulin resistance, but the connection between these two features has been unclear. Androgen synthesis is regulated in part by the...
8.
Brooke A, Taylor N, Shepherd J, Gore M, Ahmad T, Lin L, et al.
J Clin Endocrinol Metab
. 2006 Mar;
91(6):2428-31.
PMID: 16569739
Context: Combined 17alpha-hydroxylase/17,20-lyase deficiency is a rare cause of congenital adrenal hyperplasia and hypogonadism. Novel single amino acid changes in P450c17 provide potentially important insights into key structural domains for...
9.
Lutz L, Cole L, Gupta M, Kwist K, Auchus R, Hammes S
Proc Natl Acad Sci U S A
. 2001 Nov;
98(24):13728-33.
PMID: 11707587
Steroid-induced maturation of Xenopus oocytes has long served as a model for studying meiosis. Progesterone has been considered the relevant steroid controlling maturation, perhaps through interactions with classical progesterone receptors....
10.
Gupta M, Geller D, Auchus R
J Clin Endocrinol Metab
. 2001 Sep;
86(9):4416-23.
PMID: 11549685
The cytochrome P450c17 enzyme system performs both the 17alpha-hydroxylase and 17,20-lyase reactions in the human adrenal glands and gonads. This 17,20-lyase activity is required for the biosynthesis of dehydroepiandrosterone, the...