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R H Scheller

Explore the profile of R H Scheller including associated specialties, affiliations and a list of published articles. Areas
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Articles 227
Citations 11239
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Recent Articles
1.
Scales S, Yoo B, Scheller R
Proc Natl Acad Sci U S A . 2002 Jan; 98(25):14262-7. PMID: 11762430
The four-helical bundle soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor (SNARE) complex that mediates intracellular membrane fusion events contains a highly conserved ionic layer at the center of an...
2.
Scales S, Finley M, Scheller R
Science . 2001 Nov; 294(5544):1015-6. PMID: 11691976
Highly orchestrated molecular rearrangements are required for two membranes to fuse, as happens, for example, during neurotransmitter release into the synapse. In an elegant Perspective, Scales et al. discuss two...
3.
Peden A, Park G, Scheller R
J Biol Chem . 2001 Oct; 276(52):49183-7. PMID: 11598115
Heterotetrameric adaptor complexes and SNAREs play key roles in the specificity of membrane budding and fusion. Here we test the hypothesis that vesicle budding and membrane fusion are coupled by...
4.
Misura K, Gonzalez Jr L, May A, Scheller R, Weis W
J Biol Chem . 2001 Sep; 276(44):41301-9. PMID: 11533035
SNARE proteins are required for intracellular membrane fusion. In the neuron, the plasma membrane SNAREs syntaxin 1a and SNAP25 bind to VAMP2 found on neurotransmitter-containing vesicles. These three proteins contain...
5.
Matern H, Yeaman C, Nelson W, Scheller R
Proc Natl Acad Sci U S A . 2001 Aug; 98(17):9648-53. PMID: 11493706
The yeast exocyst complex (also called Sec6/8 complex in higher eukaryotes) is a multiprotein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. It is...
6.
Prekeris R, Davies J, Scheller R
J Biol Chem . 2001 Aug; 276(42):38966-70. PMID: 11481332
Rab11, a low molecular weight GTP-binding protein, has been shown to play a key role in a variety of cellular processes, including endosomal recycling, phagocytosis, and transport of secretory proteins...
7.
Foletti D, Blitzer J, Scheller R
J Neurosci . 2001 Jul; 21(15):5473-83. PMID: 11466418
The dynamic modulation of protein function by phosphorylation plays an important role in regulating synaptic plasticity. Several proteins involved in synaptic transmission have been shown to be targets of protein...
8.
Foletti D, Scheller R
J Neurosci . 2001 Jul; 21(15):5461-72. PMID: 11466417
Protein kinases and phosphatases play an important role in modulating synaptic transmission. The synaptic protein rabphilin associates with synaptic vesicles through the small GTPase Rab3A, binds Ca(2+) and phospholipids, and...
9.
Hua Y, Scheller R
Proc Natl Acad Sci U S A . 2001 Jun; 98(14):8065-70. PMID: 11427709
Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins of the syntaxin, SNAP-25, and VAMP families mediate intracellular membrane fusion through the formation of helical bundles that span opposing membranes. Soluble...
10.
Chen Y, Scales S, Jagath J, Scheller R
J Biol Chem . 2001 May; 276(30):28503-8. PMID: 11373287
Membrane fusion requires the formation of four-helical bundles comprised of the SNARE proteins syntaxin, vesicle-associated membrane protein (VAMP), and the synaptosomal-associated protein of 25 kDa (SNAP-25). Botulinum neurotoxin E cleaves...