R H McKee
Overview
Explore the profile of R H McKee including associated specialties, affiliations and a list of published articles.
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Articles
65
Citations
180
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Recent Articles
1.
Lammers J, Muijser H, Owen D, Kulig B, McKee R
Int J Toxicol
. 2011 Jan;
30(1):47-58.
PMID: 21266661
This article reports the results of neurobehavioral tests on C(5)-C(10) normal paraffinic constituents (n-paraffins). Shortly after exposure, effects were evaluated in several domains including clinical effects, motor activity, functional observations,...
2.
Hissink A, Kulig B, Kruse J, Freidig A, Verwei M, Muijser H, et al.
Int J Toxicol
. 2009 Dec;
28(6):498-509.
PMID: 19966142
This report describes a physiologically based pharmacokinetic model for cyclohexane and its use in comparing internal doses in rats and volunteers following inhalation exposures. Parameters describing saturable metabolism of cyclohexane...
3.
Lammers J, Emmen H, Muijser H, Hoogendijk E, McKee R, Owen D, et al.
Int J Toxicol
. 2009 Dec;
28(6):488-97.
PMID: 19966141
The neurobehavioral effects of inhaled cyclohexane in rats and humans are investigated to define relationships between internal doses and acute central nervous system effects. Rats are exposed for 3 consecutive...
4.
Hissink A, Kruse J, Kulig B, Verwei M, Muijser H, Salmon F, et al.
Neurotoxicology
. 2007 May;
28(4):751-60.
PMID: 17493682
As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted in...
5.
Lammers J, Emmen H, Muijser H, Hoogendijk E, McKee R, Owen D, et al.
Neurotoxicology
. 2007 Apr;
28(4):736-50.
PMID: 17433444
To evaluate the neurobehavioral effects of hydrocarbon solvents and to establish a working model for extrapolating animal test data to humans, studies were conducted which involved inhalation exposure of rats...
6.
McKee R, Lammers J, Hoogendijk E, Emmen H, Muijser H, Barsotti D, et al.
Neurotoxicology
. 2006 Jul;
27(6):1064-79.
PMID: 16831461
As a preliminary step to evaluating the acute neurobehavioral effects of hydrocarbon solvents and to establish a working model for extrapolating animal test data to humans, joint neurobehavioral/toxicokinetic studies were...
7.
Kaufmann W, Deckardt K, McKee R, Butala J, Bahnemann R
Regul Toxicol Pharmacol
. 2002 Dec;
36(2):175-83.
PMID: 12460752
Recently several chronic toxicity/carcinogenicity studies of di-isononyl phthalate (DINP) have been reported. These studies defined effect levels for liver tumors in male and female F344 rats at dietary levels exceeding...
8.
McKee R, Stoltz M, Pallas F, Lington A
J Appl Toxicol
. 2002 Oct;
22(5):293-302.
PMID: 12355558
Di-isononyl phthalate (DINP; CAS no. 68515-48-0) is a general-purpose plasticizer for polyvinyl chloride. It produced liver and kidney effects when given to rodents at high oral doses, but there were...
9.
Isenberg J, Kamendulis L, Ackley D, Smith J, Pugh Jr G, Lington A, et al.
Toxicol Sci
. 2001 Nov;
64(2):192-9.
PMID: 11719701
The tumor promotion stage of chemical carcinogenesis has been shown to exhibit a persistence of cellular effects during treatment and the reversibility of these changes upon cessation of treatment. Inhibition...
10.