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R H Dashwood

Explore the profile of R H Dashwood including associated specialties, affiliations and a list of published articles. Areas
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Articles 53
Citations 555
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Recent Articles
1.
Nolte-t Hoen E, Van Rooij E, Bushell M, Zhang C, Dashwood R, James W, et al.
J Intern Med . 2015 Apr; 278(2):99-109. PMID: 25832550
MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and...
2.
Watson G, Wickramasekara S, Palomera-Sanchez Z, Black C, Maier C, Williams D, et al.
Oncogenesis . 2014 Dec; 3:e131. PMID: 25486523
The isothiocyanate sulforaphane is a promising molecule for development as a therapeutic agent for patients with metastatic prostate cancer. Sulforaphane induces apoptosis in advanced prostate cancer cells, slows disease progression...
3.
Kang Y, Nian H, Rajendran P, Kim E, Dashwood W, Pinto J, et al.
Cell Death Dis . 2014 Oct; 5:e1476. PMID: 25321483
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate...
4.
Ashktorab H, Belgrave K, Hosseinkhah F, Brim H, Nouraie M, Takkikto M, et al.
Dig Dis Sci . 2008 Dec; 54(10):2109-17. PMID: 19057998
Chromatin remodeling and activation of transcription are important aspects of gene regulation, but these often go awry in disease progression, including during colon cancer development. We investigated the status of...
5.
Li Q, Dashwood W, Zhong X, Nakagama H, Dashwood R
Oncogene . 2007 Apr; 26(42):6194-202. PMID: 17404573
Beta-catenin/T-cell factor (Tcf) signaling is constitutively active in the majority of human colorectal cancers, and there are accompanying changes in Bcl-2 expression. Similarly, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP)-induced colon tumors in the rat...
6.
Dashwood R, Xu M
Food Chem Toxicol . 2003 Jul; 41(8):1185-92. PMID: 12842187
Indole-3-carbinol (I3C), a compound found in cruciferous vegetables, inhibits the formation of DNA adducts, colonic aberrant crypts, and tumors in rats given heterocyclic amines, such as 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Previous mechanism...
7.
Santana-Rios G, Orner G, Xu M, Izquierdo-Pulido M, Dashwood R
Nutr Cancer . 2002 Jul; 41(1-2):98-103. PMID: 12094635
There is growing interest in the potential health benefits of tea, including the anticarcinogenic properties. We report here that white tea, the least processed form of tea, is a potent...
8.
Santana-Rios G, Orner G, Amantana A, Provost C, Wu S, Dashwood R
Mutat Res . 2001 Jul; 495(1-2):61-74. PMID: 11448643
There is growing interest in the potential health benefits of tea, including the antimutagenic properties. Four varieties of white tea, which represent the least processed form of tea, were shown...
9.
Yu Z, Xu M, Santana-Rios G, Shen R, Izquierdo-Pulido M, Williams D, et al.
Food Chem Toxicol . 2001 Jun; 39(7):655-65. PMID: 11397513
Refined wheat, unrefined whole wheat, and wheat bran were studied for their ability to protect against heterocyclic amines (HCAs) in vitro and in vivo. Wheat bran, which binds HCAs in...
10.
Dashwood R, Xu M, Orner G, Horio D
Eur J Cancer Prev . 2001 May; 10(2):139-45. PMID: 11330454
Sodium-copper chlorophyllin (CHL) inhibits the formation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced colonic aberrant crypt foci (ACF) and tumours in the F344 rat when it is given simultaneously with either...